Elliott DA, Cowgill LD. Acute renal failure. In:Kirk RW, ed.Current veterinary therapy XIII: small animal practice. Philadelphia: WB Saunders Co, 2000;173–178.
Lane IF, Grauer GF, Fettman MJ. Acute renal failure. Part I. Risk factors, prevention, and strategies for protection. Compend Contin Educ Pract Vet 1994;16:15–29.
Brady HR, Brenner BM, Lieberthal W. Acute renal failure. In:Brenner BM, Rector FC, ed.The kidney. Philadelphia: WB Saunders Co, 1991;1200–1241.
Vaden SL, Levine J, Breitschwerdt EB. A retrospective case-control of acute renal failure in 99 dogs. J Vet Intern Med 1997;11:58–64.
Behrend EN, Grauer GF, Mani I, et al. Hospital-acquired acute renal failure in dogs: 29 cases (1983–1992). J Am Vet Med Assoc 1996;208:537–541.
Langston CE. Acute renal failure caused by lily ingestion in six cats. J Am Vet Med Assoc 2002;220:49–52.
Gookin JL, Riviere JE, Gilger C, et al. Acute renal failure in four cats treated with paromomycin. J Am Vet Med Assoc 1999;215:1821–1823.
Fulton RB, Fruechte LK. Poisoning induced by administration of a phosphate-containing urinary acidifier in a cat. J Am Vet Med Assoc 1991;198:883–885.
Mealey KL, Boothe DM. Nephrotoxicosis associated with topical administration of gentamicin in a cat. J Am Vet Med Assoc 1994;204:1919–1921.
Gulledge L, Boos D, Wachsstock R. Acute renal failure in a cat secondary to Tiger Lily (Lilium tigrinum) toxicity. Feline Pract 1997;25 (5–6):38–39
Hadley RM, Richardson JA, Gwaltney-Brant SM. Short communications: a retrospective study of daylily toxicosis in cats. Vet Human Toxicol 2003;45:38–39.
Landerville AJ, Seshadri R. Utilization of continuous renal replacement therapy in a case of feline acute renal failure. J Vet Emerg Crit Care 2004;14:278–286.
Brady MA, Janovitz EB. Nephrotoxicosis in a cat following ingestion of Asiatic hybrid lily (Lilium sp.). J Vet Diagn Invest 2000;12:566–568.
Ympa YP, Sakr Y, Reinhart K, et al. Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med 2005;118:827–832.
Langston CE, Cowgill LD, Spano JA. Applications and outcome of hemodialysis in cats: a review of 29 cases. J Vet Intern Med 1997;11:348–355.
Elliott J, Syme HM, Markwell PJ. Acid-base balance of cats with chronic renal failure: effect of deterioration in renal function. J Small Anim Pract 2003;44:261–268.
Elliott J, Syme HM, Reubens E, et al. Assessment of acid-base status of cats with naturally occurring chronic renal failure. J Small Anim Pract 2003;44:65–70.
Obialo CI, Okonofua EC, Nzerue MC, et al. Role of hypoalbuminemia and hypocholesterolemia as copredictors of mortality in acute renal failure. Kidney Int 1999;56:1058–1063.
Mahajan S, Tiwari S, Bharani R, et al. Spectrum of acute renal failure and factors predicting its outcome in an intensive care unit in India. Renal Failure 2006;28:119–124.
Francey T. Outcomes of patients treated with hemodialysis, in Proceedings. Advanced Renal Ther Symp 2004;CD-ROM.
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Objective—To determine patient demographics, clinicopathologic findings, and outcome associated with naturally acquired acute intrinsic renal failure (ARF) in cats.
Design—Retrospective case series.
Animals—32 cats with ARF.
Procedures—Cats were considered to have ARF if they had acute onset of clinical signs (< 7 days), serum creatinine concentration > 2.5 mg/dL (reference range, 0.8 to 2.3 mg/dL) and BUN > 35 mg/dL (reference range, 15 to 34 mg/dL) in conjunction with urine specific gravity < 1.025 or with anuria or increasing serum creatinine concentration despite fluid therapy and normal hydration status, and no signs of chronic renal disease. Cases were excluded if cats had renal calculi or renal neoplasia.
Results—Causes of ARF included nephrotoxins (n = 18 cats), ischemia (4), and other causes (10). Eighteen cats were oliguric. For each unit (mEq/L) increase in initial potassium concentration, there was a 57% decrease in chance of survival. Low serum albumin or bicarbonate concentration at initial diagnosis was a negative prognostic indicator for survival. Initial concentrations of BUN, serum creatinine, and other variables were not prognostic. Seventeen (53%) cats survived, of which 8 cats had resolution of azotemia and 9 cats were discharged from the hospital with persistent azotemia.
Conclusions and Clinical Relevance—Results suggested that survival rates of cats with ARF were similar to survival rates in dogs and that residual renal damage persisted in approximately half of cats surviving the initial hospitalization.
Dr. Worwag's present address is Garden State Veterinary Specialists, 1 Pine St, Tinton Falls, NJ 07753.