• 1.

    Ghio S, Gavazzi A, Campana C, et al. Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol. 2001;37(1):183188.

    • Search Google Scholar
    • Export Citation
  • 2.

    Ghio S, Guazzi M, Scardovi AB, et al. Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction. Eur J Heart Fail. 2017;19(7):873879.

    • Search Google Scholar
    • Export Citation
  • 3.

    van Wolferen SA, Marcus JT, Boonstra A, et al. Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. Eur Heart J. 2007;28(10):12501257.

    • Search Google Scholar
    • Export Citation
  • 4.

    Brierre G, Blot-Souletie N, Degano B, Têtu L, Bongard V, Carrié D. New echocardiographic prognostic factors for mortality in pulmonary arterial hypertension. Eur J Echocardiogr. 2010;11(6):516522.

    • Search Google Scholar
    • Export Citation
  • 5.

    Borgarelli M, Abbott J, Braz-Ruivo L, et al. Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease. J Vet Intern Med. 2015;29(2):569574.

    • Search Google Scholar
    • Export Citation
  • 6.

    Visser LC, Wood JE, Johnson LR. Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension. J Vet Intern Med. 2020;34(4):13791388.

    • Search Google Scholar
    • Export Citation
  • 7.

    Reinero C, Visser LC, Kellihan HB, et al. ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs. J Vet Intern Med. 2020;34(2):549573.

    • Search Google Scholar
    • Export Citation
  • 8.

    Hoeper MM, Bogaard HJ, Condliffe R, et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013;62(suppl 25):D42D50.

    • Search Google Scholar
    • Export Citation
  • 9.

    Maughan WL, Shoukas AA, Sagawa K, Weisfeldt ML. Instantaneous pressure-volume relationship of the canine right ventricle. Circ Res. 1979;44(3):309315.

    • Search Google Scholar
    • Export Citation
  • 10.

    Amundsen BH, Helle-Valle T, Edvardsen T, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: Validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006;47(4):789793.

    • Search Google Scholar
    • Export Citation
  • 11.

    Johnson L, Boon J, Orton EC. Clinical characteristics of 53 dogs with Doppler-derived evidence of pulmonary hypertension: 1992–1996. J Vet Intern Med. 1999;13(5):440447.

    • Search Google Scholar
    • Export Citation
  • 12.

    Hsiao S-H, Lin S-K, Wang W-C, Yang S-H, Gin P-L, Liu C-P. Severe tricuspid regurgitation shows significant impact in the relationship among peak systolic tricuspid annular velocity, tricuspid annular plane systolic excursion, and right ventricular ejection fraction. J Am Soc Echocardiogr. 2006;19(7):902910.

    • Search Google Scholar
    • Export Citation
  • 13.

    Caplin JL, Flatman WD, Dyke L, Wiseman MN, Dymond DS. Influence of respiratory variations on right ventricular function. Br Heart J. 1989;62(4):253259.

    • Search Google Scholar
    • Export Citation
  • 14.

    Summer WR, Permutt S, Sagawa K, Shoukas AA, Bromberger-Barnea B. Effects of spontaneous respiration on canine left ventricular function. Circ Res. 1979;45(6):719728.

    • Search Google Scholar
    • Export Citation
  • 15.

    Mitchell JR, Whitelaw WA, Sas R, Smith ER, Tyberg JV, Belenkie I. RV filling modulates LV function by direct ventricular interaction during mechanical ventilation. Am J Physiol Heart Circ Physiol. 2005;289(2):H549H557.

    • Search Google Scholar
    • Export Citation
  • 16.

    Cherpanath TGV, Simonis FD, Bouma BJ, et al. Myocardial function during low versus intermediate tidal volume ventilation in patients without acute respiratory distress syndrome. Anesthesiology. 2020;132(5):11021113.

    • Search Google Scholar
    • Export Citation
  • 17.

    Brimioulle S, Wauthy P, Ewalenko P, et al. Single-beat estimation of right ventricular end-systolic pressure-volume relationship. Am J Physiol Heart Circ Physiol. 2003;284(5):H1625H1630.

    • Search Google Scholar
    • Export Citation
  • 18.

    Visser LC, Scansen BA, Schober KE, Bonagura JD. Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs: Repeatability and reference intervals. J Vet Cardiol. 2015;17(2):8396.

    • Search Google Scholar
    • Export Citation
  • 19.

    Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the american society of echocardiography. Endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685713.

    • Search Google Scholar
    • Export Citation
  • 20.

    Gentile-Solomon JM, Abbott JA. Conventional echocardiographic assessment of the canine right heart: reference intervals and repeatability. J Vet Cardiol. 2016;18(3):234247.

    • Search Google Scholar
    • Export Citation
  • 21.

    Vezzosi T, Domenech O, Costa G, et al. Echocardiographic evaluation of the right ventricular dimension and systolic function in dogs with pulmonary hypertension. J Vet Intern Med. 2018;32(5):15411548.

    • Search Google Scholar
    • Export Citation
  • 22.

    Yuchi Y, Suzuki R, Teshima T, Matsumoto H, Koyama H. Utility of tricuspid annular plane systolic excursion normalized by right ventricular size indices in dogs with postcapillary pulmonary hypertension. J Vet Intern Med. 2021;35(1):107119.

    • Search Google Scholar
    • Export Citation
  • 23.

    Pariaut R, Saelinger C, Strickland KN, Beaufrère H, Reynolds CA, Vila J. Tricuspid annular plane systolic excursion (TAPSE) in dogs: reference values and impact of pulmonary hypertension. J Vet Intern Med. 2012;26(5):11481154.

    • Search Google Scholar
    • Export Citation
  • 24.

    Caivano D, Dickson D, Pariaut R, Stillman M, Rishniw M. Tricuspid annular plane systolic excursion-to-aortic ratio provides a bodyweight-independent measure of right ventricular systolic function in dogs. J Vet Cardiol. 2018;20(2):7991.

    • Search Google Scholar
    • Export Citation
  • 25.

    Morita T, Nakamura K, Osuga T, et al. Effect of acute volume overload on echocardiographic indices of right ventricular function and dyssynchrony assessed by use of speckle tracking echocardiography in healthy dogs. Am J Vet Res. 2019;80(1):5160.

    • Search Google Scholar
    • Export Citation
  • 26.

    Suzuki R, Mochizuki Y, Yuchi Y, et al. Assessment of myocardial function in obstructive hypertrophic cardiomyopathy cats with and without response to medical treatment by carvedilol. BMC Vet Res. 2019;15(1):376.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 27.

    Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48(3):452458.

    • Search Google Scholar
    • Export Citation
  • 28.

    Jardin F, Delorme G, Hardy A, Auvert B, Beauchet A, Bourdias JP. Reevaluation of hemodynamic consequences of positive pressure ventilation: Emphasis on cyclic right ventricular afterloading by mechanical lung inflation. Anesthesiology. 1990;72(6):966970.

    • Search Google Scholar
    • Export Citation
  • 29.

    Pinsky MR. Determinants of pulmonary arterial flow variation during respiration. J Appl Physiol Respir Environ Exerc Physiol. 1984;56(5):12371245.

    • Search Google Scholar
    • Export Citation
  • 30.

    Pinsky MR. Instantaneous venous return curves in an intact canine preparation. J Appl Physiol Respir Environ Exerc Physiol. 1984;56(3):765771.

    • Search Google Scholar
    • Export Citation
  • 31.

    Visser LC, Sintov DJ, Oldach MS. Evaluation of tricuspid annular plane systolic excursion measured by two-dimensional echocardiography in healthy dogs: repeatability, reference intervals, and comparison with M-mode assessment. J Vet Cardiol. 2018;20(3):165174.

    • Search Google Scholar
    • Export Citation
  • 32.

    Açar G, Alizade E, Avci A, et al. Effect of blood donation-mediated volume reduction on regional right ventricular deformation in healthy subjects. Int J Cardiovasc Imaging. 2014;30(3):543548.

    • Search Google Scholar
    • Export Citation
  • 33.

    Starr I, Jeffers WA, Meade RH. The absence of conspicuous increments of venous pressure after severe damage to the right ventricle of the dog, with a discussion of the relation between clinical congestive failure and heart disease. Am Heart J. 1943;26:291301.

    • Search Google Scholar
    • Export Citation
  • 34.

    Donald DE, Essex HE. Pressure studies after inactivation of the major portion of the canine right ventricle. Am J Physiol. 1954;176(1):155161.

    • Search Google Scholar
    • Export Citation
  • 35.

    Chapel EH, Scansen BA, Schober KE, Bonagura JD. Echocardiographic estimates of right ventricular systolic function in dogs with myxomatous mitral valve disease. J Vet Intern Med. 2018;32(1):6471.

    • Search Google Scholar
    • Export Citation
  • 36.

    Poser H, Berlanda M, Monacolli M, Contiero B, Coltro, Guglielmini C. Tricuspid annular plane systolic excursion in dogs with myxomatous mitral valve disease with and without pulmonary hypertension. J Vet Cardiol. 2017;19(3):228239.

    • Search Google Scholar
    • Export Citation
  • 37.

    Mezidi M, Guérin C. Effects of patient positioning on respiratory mechanics in mechanically ventilated ICU patients. Ann Transl Med. 2018;6(19):384.

    • Search Google Scholar
    • Export Citation
  • 38.

    Priebe HJ. Differential effects of isoflurane on regional right and left ventricular performances, and on coronary, systemic, and pulmonary hemodynamics in the dog. Anesthesiology. 1987;66(3):262272.

    • Search Google Scholar
    • Export Citation
  • 39.

    Kerbaul F, Rondelet B, Motte S, et al. Isoflurane and desflurane impair right ventricular-pulmonary arterial coupling in dogs. Anesthesiology. 2004;101(6):13571362.

    • Search Google Scholar
    • Export Citation
  • 40.

    Lisciandro GR. The use of the diaphragmatico-hepatic (DH) views of the abdominal and thoracic focused assessment with sonography for triage (AFAST/TFAST) examinations for the detection of pericardial effusion in 24 dogs (2011–2012). J Vet Emerg Crit Care (San Antonio). 2016;26(1):125131.

    • Search Google Scholar
    • Export Citation
  • 41.

    Jones SR, Carley S, Harrison M. An introduction to power and sample size estimation. Emerg Med J. 2003;20(5):453458.

  • 42.

    Vitarelli A, Terzano C. Do we have two hearts? New insights in right ventricular function supported by myocardial imaging echocardiography. Heart Fail Rev. 2010;15(1):3961.

    • Search Google Scholar
    • Export Citation
  • 43.

    Caivano D, Rishniw M, Birettoni F, Petrescu V-F, Porciello F. Transverse right ventricle strain and strain rate assessed by 2-dimensional speckle tracking echocardiography in dogs with pulmonary hypertension. Vet Sci. 2020;7(1):110.

    • Search Google Scholar
    • Export Citation

Investigation of the influence of manual ventilation-controlled respiration on right ventricular pressure-volume loops and echocardiographic variables in healthy anesthetized dogs

Yunosuke Yuchi DVM1, Ryohei Suzuki DVM, PhD1, Takahiro Teshima DVM, PhD1, Hirotaka Matsumoto DVM, PhD1, and Hidekazu Koyama DVM, PhD1
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  • 1 From the Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo, 180-8602, Japan.

Abstract

OBJECTIVE

To evaluate the influence of manual ventilation-controlled respiration on right ventricular (RV) pressure-volume loop–derived and echocardiographic variables in dogs.

ANIMALS

8 healthy, anesthetized Beagles.

PROCEDURES

In a prospective experimental study, pressure-volume catheters were percutaneously inserted into the right ventricle of each dog, and manual ventilation was performed; RV pressure-volume loop (hemodynamic) data and conventional echocardiographic variables were assessed. Two-dimensional speckle tracking echocardiography–derived RV strain (RVS) and RV systolic strain rate (RVSR) were obtained with RV free wall–only analysis (free wall) and RV global analysis (RVGA; interventricular septum). Variables were compared between end-inspiratory and end-expiratory phases of respiration by statistical methods. Multiple regression analysis was used to assess associations between selected hemodynamic and echocardiographic variables.

RESULTS

The RV pressure significantly increased, and RV volume, stroke volume, tricuspid annular plane systolic excursion, RV fractional area change, peak myocardial systolic velocity of the lateral tricuspid annulus, and RV free wall only–assessed RVS and RVSR significantly decreased in the inspiratory phase, compared with the expiratory phase. There were no significant differences in end-systolic elastance or RVGA-assessed RVS or RVSR between respiratory phases. The RVGA-assessed RVSR was significantly associated with stroke volume and end-systolic elastance.

CONCLUSIONS AND CLINICAL RELEVANCE

Specific RV echocardiographic variables were significantly affected by respiration. In contrast, RVS and RVSR determined with RVGA were not affected by respiration and were associated with hemodynamic indicators of RV contractility.

Abstract

OBJECTIVE

To evaluate the influence of manual ventilation-controlled respiration on right ventricular (RV) pressure-volume loop–derived and echocardiographic variables in dogs.

ANIMALS

8 healthy, anesthetized Beagles.

PROCEDURES

In a prospective experimental study, pressure-volume catheters were percutaneously inserted into the right ventricle of each dog, and manual ventilation was performed; RV pressure-volume loop (hemodynamic) data and conventional echocardiographic variables were assessed. Two-dimensional speckle tracking echocardiography–derived RV strain (RVS) and RV systolic strain rate (RVSR) were obtained with RV free wall–only analysis (free wall) and RV global analysis (RVGA; interventricular septum). Variables were compared between end-inspiratory and end-expiratory phases of respiration by statistical methods. Multiple regression analysis was used to assess associations between selected hemodynamic and echocardiographic variables.

RESULTS

The RV pressure significantly increased, and RV volume, stroke volume, tricuspid annular plane systolic excursion, RV fractional area change, peak myocardial systolic velocity of the lateral tricuspid annulus, and RV free wall only–assessed RVS and RVSR significantly decreased in the inspiratory phase, compared with the expiratory phase. There were no significant differences in end-systolic elastance or RVGA-assessed RVS or RVSR between respiratory phases. The RVGA-assessed RVSR was significantly associated with stroke volume and end-systolic elastance.

CONCLUSIONS AND CLINICAL RELEVANCE

Specific RV echocardiographic variables were significantly affected by respiration. In contrast, RVS and RVSR determined with RVGA were not affected by respiration and were associated with hemodynamic indicators of RV contractility.

Contributor Notes

Address correspondence to Dr. Suzuki (ryoheisuzuki@nvlu.ac.jp).