Influence of dietary calcium and phosphorus content in a fixed ratio on growth and development in Great Danes

Susan D. Lauten Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Susan D. Lauten in
Current site
Google Scholar
PubMed
Close
 PhD
,
Nancy R. Cox Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Nancy R. Cox in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
William R. Brawner Jr Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by William R. Brawner Jr in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Susan A. Goodman Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Susan A. Goodman in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
John T. Hathcock Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by John T. Hathcock in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Ronald D. Montgomery Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Ronald D. Montgomery in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Steven A. Kincaid Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Steven A. Kincaid in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Nancy E. Morrison Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Nancy E. Morrison in
Current site
Google Scholar
PubMed
Close
 MS
,
Joseph S. Spano Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Joseph S. Spano in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Allan. J. Lepine Iams Company, Lewisburg, OH 45338.

Search for other papers by Allan. J. Lepine in
Current site
Google Scholar
PubMed
Close
 PhD
,
Gregory A. Reinhart Iams Company, Lewisburg, OH 45338.

Search for other papers by Gregory A. Reinhart in
Current site
Google Scholar
PubMed
Close
 PhD
, and
Henry J. Baker Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849.

Search for other papers by Henry J. Baker in
Current site
Google Scholar
PubMed
Close
 DVM

Click on author name to view affiliation information

Abstract

Objective—To study the musculoskeletal development of Great Dane puppies fed various dietary concentrations of calcium (Ca) and phosphorus (P) in fixed ratio by use of dual energy x-ray absorptiometry (DEXA), determination of serum insulin-like growth factor I and parathyroid hormone concentrations, radiography, and blood chemistry analysis results.

Animals—32 purebred Great Dane puppies from 4 litters.

Procedure—At weaning, puppies were assigned randomly to 1 of 3 diets. Blood was collected for biochemical analyses and hormone assays, and radiography and DEXA were performed through 18 months of age. Changes in body weight, bone mineral content, fat tissue weight, lean mass, result of serum biochemical analyses, hormonal concentrations, and radius lengths were analyzed through 18 months of age.

Results—Bone mineral content of puppies correlated positively with Ca and P content of the diets fed. Significant differences between groups in bone mineral content, lean mass, and body fat were apparent early. The disparity among groups increased until 6 months of age and then declined until body composition was no longer different at 12 months of age. Accretion rates for skeletal mineral content, fat, and lean tissue differed from each other and by diet group.

Conclusions and Clinical Relevance—Ca and P concentrations in the diet of young Great Dane puppies are rapidly reflected in the bone mineral content of the puppies until 5 to 6 months of age, after which hormonal regulation adjusts absorption and excretion of these minerals. Appropriate Ca and P concentrations in diets are important in young puppies < 6 months of age. (Am J Vet Res 2002;63:1036–1047)

Abstract

Objective—To study the musculoskeletal development of Great Dane puppies fed various dietary concentrations of calcium (Ca) and phosphorus (P) in fixed ratio by use of dual energy x-ray absorptiometry (DEXA), determination of serum insulin-like growth factor I and parathyroid hormone concentrations, radiography, and blood chemistry analysis results.

Animals—32 purebred Great Dane puppies from 4 litters.

Procedure—At weaning, puppies were assigned randomly to 1 of 3 diets. Blood was collected for biochemical analyses and hormone assays, and radiography and DEXA were performed through 18 months of age. Changes in body weight, bone mineral content, fat tissue weight, lean mass, result of serum biochemical analyses, hormonal concentrations, and radius lengths were analyzed through 18 months of age.

Results—Bone mineral content of puppies correlated positively with Ca and P content of the diets fed. Significant differences between groups in bone mineral content, lean mass, and body fat were apparent early. The disparity among groups increased until 6 months of age and then declined until body composition was no longer different at 12 months of age. Accretion rates for skeletal mineral content, fat, and lean tissue differed from each other and by diet group.

Conclusions and Clinical Relevance—Ca and P concentrations in the diet of young Great Dane puppies are rapidly reflected in the bone mineral content of the puppies until 5 to 6 months of age, after which hormonal regulation adjusts absorption and excretion of these minerals. Appropriate Ca and P concentrations in diets are important in young puppies < 6 months of age. (Am J Vet Res 2002;63:1036–1047)

All Time Past Year Past 30 Days
Abstract Views 206 0 0
Full Text Views 784 440 20
PDF Downloads 541 194 9
Advertisement