In the JAVMA article, “Acute pyelonephritis in cats is frequently caused by Escherichia coli resistant to potentiated penicillins but has a better prognosis than other causes of acute kidney injury,” published in the February issue (J Am Vet Med Assoc. 2024;262(2):232–240. doi.org/10.2460/javma.23.08.0488), The authors would like to resubmit Table 4 in its entirety to address multiple errors. The corrected table should appear as follows:
—Urinary Escherichia coli isolates with susceptibility testing from cats described in Table 1 with their associated minimum inhibitory concentrations (MICs) for the classes of antibiotic used in the treatment of this cohort. All urine samples were collected via cystocentesis, and Clinical and Laboratory Standards Institute (CLSI) breakpoints were used to determine the percent suscep- tible to the selected antibiotics.
| Class | Antimicrobial | MIC frequency (μg/mL) | MIC breakpoint (μg/mL) | Percent susceptible |
|---|---|---|---|---|
| Penicillin | Ampicillin | > 1 (n = 20) | ≤ 0.252 | 0 |
| ≤ 2 (n = 9) | ||||
| 4 (n = 2) | ||||
| 16 (n = 1) | ||||
| ≥ 32 (n = 1) | ||||
| Amoxi-clav | > 1 (n = 10) | ≤ 0.25/0.122 | 0 | |
| ≤ 2 (n = 9) | ||||
| 4 (n = 13) | ||||
| 8 (n = 1) | ||||
| Cephalosporin (first gen) | Cephalexin | 4 (n = 14) | ≤ 23 | 0 |
| 8 (n = 7) | ||||
| > 8 (n = 4) | ||||
| Cephalosporin (third gen) | Cefpodoxime | ≤ 1 (n = 22) | ≤ 24 | 92 |
| ≤ 2 (n = 9) | ||||
| > 16 (n = 2) | ||||
| Fluoroquinolone | Enrofloxacin | ≤ 0.25 (n = 29) | ≤ 0.52 | 97 |
| > 2 (n = 1) | ||||
| Marbofloxacin | ≤ 0.5 (n = 29) | ≤ 12 | 97 | |
| > 2 (n = 1) | ||||
| Orbifloxacin1 | ≤ 1 (n = 15) | ≤ 12 | 100 | |
| Pradofloxacin1 | ≤ 0.25 (n = 15) | ≤ 0.255 | 100 |
1 Antimicrobials added to Kansas State University Veterinary Health Center panel January 2016. Orbifloxacin and pradofloxacin were not tested on all isolates.
2 CLSI breakpoint, feline skin and soft tissue.
3 CLSI breakpoint, canine skin and soft tissue.
4 CLSI breakpoint, canine wound, abscess, and urinary tract.
5 CLSI breakpoint, feline respiratory, skin, and soft tissue.
Amoxi-clav = Amoxicillin-clavulanate. Gen = Generation.
