Funded in part by the Ott Endowment.
The authors declare that there were no conflicts of interest.
The authors thank the cat owners who contributed samples from their cats to the DNA bank at the College of Veterinary Medicine, Washington State University.
Centragard, Boehringer Ingelheim, Duluth, Ga.
Broadline, Boehringer Ingelheim, North Ryde, NSW, Australia.
Heartgard Plus, Boehringer Ingelheim, Duluth, Ga.
Quick-gDNA FFPE Kit D3067d, Zymo Research, Irvine, Calif.
Applied Biosystems AB3730 genetic analyzer, Thermo Fisher Scientific, Waltham, Mass.
Applied Biosystems GeneMapper 5 software, Thermo Fisher Scientific, Waltham, Mass.
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Coelho JC, Tucker R, Mattoon J, et al. Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1∆ mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiency. J Vet Pharmacol Ther 2009;32:417–421.
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)| false , Coelho JC , Tucker R , Mattoon J Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1∆ mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiency. J Vet Pharmacol Ther 2009; 32: 417– 421. 10.1111/j.1365-2885.2009.01068.x
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Richards B, Skoletsky J, Shuber AP, et al. Multiplex PCR amplification from the CFTR gene using DNA prepared from buccal brushes/swabs. Hum Mol Genet 1993;2:159–163.
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Merola VM, Eubig PA. Toxicology of avermectins and milbemycins (macrocyclic lactones) and the role of P-glycoprotein in dogs and cats. Vet Clin North Am Small Anim Pract 2018;48:991–1012.
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Jourdan G, Boyer G, Raymond-Letron I, et al. Intravenous lipid emulsion therapy in 20 cats accidentally overdosed with ivermectin. J Vet Emerg Crit Care (San Antonio) 2015;25:667–671.
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Wright HM, Chen AV, Talcott PA, et al. Intravenous fat emulsion as treatment for ivermectin toxicosis in three dogs homozygous for the ABCB1-1∆ gene mutation. J Vet Emerg Crit Care (San Antonio) 2011;21:666–672.