A 12-year-old 5.4-kg (11.88-lb) spayed female Miniature Dachshund was referred for evaluation of a left head tilt and vestibular ataxia. The dog had become progressively ataxic over the preceding 3 days. Initially, the dog was presented to the primary veterinarian, who performed a CBC and serum biochemical panel; there were no important hematologic findings, and moderately high alanine transaminase activity (237 U/L; reference range, 10 to 125 U/L) and mild hyperglobulinemia (4.6 g/dL; reference range, 2.5 to 4.5 g/dL) were identified. The dog was given maropitant citrate (1 mg/kg [0.45 mg/lb], SC, once) just prior to referral. At the referral hospital, physical examination of the dog revealed mild dental tartar but no other abnormalities. Neurologic examination findings included right-sided vestibular signs. The dog paced in circles to the left; the menace and nasocortical stimulation responses on the right side were absent. Shortly after being admitted to the hospital, the dog developed generalized seizures.
The authors declare no financial or other conflicts of interest.
Signa HDxt 3.0T MRI, General Electric, Milwaukee, Wis.
- 1. ↑
Cooper JJ, Schatzberg SJ, Vernau KM, et al. Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review. J Vet Intern Med 2014;28:198–203.
- 2. ↑
Estey CM, Scott SJ, Cerda-Gonzalez S. Necrotizing meningoencephalitis in a large mixed-breed dog. J Am Vet Med Assoc 2014;245:1274–1278.
- 3. ↑
Talarico LR, Schatzberg S. Idiopathic granulomatous and necrotising inflammatory disorders of the canine central nervous system: a review and future perspectives. J Small Anim Pract 2010;51:138–149.
- 4. ↑
Barber RM, Porter BF, Li Q, et al. Broadly reactive polymerase chain reaction for pathogen detection in canine granulomatous meningoencephalomyelitis and necrotizing meningoencephalitis. J Vet Intern Med 2012;26:962–968.
- 5. ↑
Coates JR, Jeffery ND. Perspectives on meningoencephalomyelitis of unknown origin. Vet Clin North Am Small Anim Pract 2014;44:1157–1185.
- 6. ↑
Hoon-Hanks LL, McGrath S, Tyler KL, et al. Metagenomic investigation of idiopathic meningoencephalomyelitis in dogs. J Vet Intern Med 2018;32:324–330.
- 7. ↑
Jung D-I, Kang B-T, Park C, et al. A Comparison of combination therapy (cyclosporine plus prednisolone) with sole prednisolone therapy in 7 dogs with necrotizing meningoencephalitis. J Vet Med Sci 2007;69:1303–1306.
- 8. ↑
Levine JM, Fosgate GT, Porter B, et al. Epidemiology of necrotizing meningoencephalitis in pug dogs. J Vet Intern Med 2008;22:961–968.