A 10-year-old 4.8-kg (10.6-lb) spayed female domestic shorthair cat was evaluated because of a 4-week history of progressive asymmetrical paraparesis (left pelvic limb more affected than the right pelvic limb). Palpation of the lumbar portion of the vertebral column elicited mild signs of pain, which resolved following treatment with anti-inflammatory doses of prednisolonea (1 mg/kg/d [0.45 mg/lb/d], PO, for 5 days [tapering dosage]). However, the cat's paraparesis did not improve and continued to progress despite corticosteroid treatment and administration of clindamycin hydrochlorideb (12 mg/kg [5.5 mg/lb], PO, q 12 h) for 4 weeks. Results of radiography and abdominal ultrasonography were unremarkable. Clinicopathologic findings included mild leukocytosis with mild neutrophilia. There were no notable findings on general physical examination. When the cat was ambulatory with mild paraparesis (worse on the left side), MRI and analysis of a CSF sample had been performed; a neurologic examination was performed 3 weeks later.
What is the problem? Where is the lesion? What are the most probable causes of this problem? What is your plan to establish a diagnosis? Please turn the page.
Prednisolone, Lloyd Inc, Shenandoah, Iowa.
Clindamycin, Lannett Company Inc, Philadelphia, Pa.
1.0 Tesla GE LX Signa Echospeed MRI, GE Medical Systems, Milwaukee, Wis.
Dotarem, Guerbet LLC, Bloomington, Ind.
1. Marioni-Henry K, Vite CH, Newton AL, et al. Prevalence of diseases of the spinal cord of cats. J Vet Intern Med 2004; 18:851–858.
2. Marioni-Henry K, Van Winkle TJ, Smith SH, et al. Tumors affecting the spinal cord of cats: 85 cases (1980–2005). J Am Vet Med Assoc 2008;232:237–243.
3. Lane SB, Kornegay JN, Duncan JR, et al. Feline spinal lymphosarcoma: a retrospective evaluation of 23 cats. J Vet Intern Med 1994;8:99–104.
4. Rissi DR, Miller AD. Feline glioma: a retrospective study and review of the literature. J Feline Med Surg 2017;19:1307–1314.
5. Hammond JJ, deLahunta A, Glass EN, et al. Feline spinal cord gliomas: clinicopathologic and diagnostic features of seven cases. J Vet Diagn Invest 2014;26:513–520.
6. Gutierrez-Quintana R, Penderis J, Anderson TJ. What Is Your Neurologic Diagnosis? J Am Vet Med Assoc 2014;244:791–793.
7. Stigen O, Yrehus B, Eggertsdottir AV. Spinal cord astrocytoma in a cat. J Small Anim Pract 2001;42:306–310.
9. Parent JM, Isler C, Holmberg DL, et al. Intramedullary spinal glioblastoma in a cat, presented as a cauda equina syndrome. Can Vet J 1982;23:169–172.
10. Troxel MT, Vite CH, Massicotte C, et al. Magnetic resonance imaging features of feline intracranial neoplasia: retrospective analysis of 46 cats. J Vet Intern Med 2004;18:176–189.