• 1. Berghoff N, Steiner JM. Laboratory tests for the diagnosis and management of chronic canine and feline enteropathies. Vet Clin North Am Small Anim Pract 2011;41:311328.

    • Search Google Scholar
    • Export Citation
  • 2. Cave NJ. Hydrolyzed protein diets for dogs and cats. Vet Clin North Am Small Anim Pract 2006;36:12511268, vi.

  • 3. Kleine-Tebbe J, Wassmann-Otto A, Monnikes H. Food allergy and intolerance: distinction, definitions and delimitation. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016;59:705722.

    • Search Google Scholar
    • Export Citation
  • 4. Clapper GM, Grieshop CM, Merchen NR, et al. Ileal and total tract nutrient digestibilities and fecal characteristics of dogs as affected by soybean protein inclusion in dry, extruded diets. J Anim Sci 2001;79:15231532.

    • Search Google Scholar
    • Export Citation
  • 5. Solms J, Vuataz L, Egli RH. The taste of L- and D-amino acids. Experientia 1965;21:692694.

  • 6. Adler-Nissen J. Methods in food protein hydrolysis. In: Adler-Nissen J, ed. Enzymic hydrolysis of food proteins. New York: Elsevier Applied Science Publishers, 1986;110130.

    • Search Google Scholar
    • Export Citation
  • 7. Biourge VC, Fontaine J, Vroom MW. Diagnosis of adverse reactions to food in dogs: efficacy of a soy-isolate hydrolyzate-based diet. J Nutr 2004;134:2062S2064S.

    • Search Google Scholar
    • Export Citation
  • 8. Loeffler A, Lloyd DH, Bond R, et al. Dietary trials with a commercial chicken hydrolysate diet in 63 pruritic dogs. Vet Rec 2004;154:519522.

    • Search Google Scholar
    • Export Citation
  • 9. Teichberg S, Lifshitz F, Pergolizzi R, et al. Response of rat intestine to a hyperosmotic feeding. Pediatr Res 1978;12:720725.

  • 10. Fruto LV. Current concepts: management of diarrhea in acute care. J Wound Ostomy Continence Nurs 1994;21:199205.

  • 11. Ladas SD, Isaacs PE, Sladen GE. Post-prandial changes of osmolality and electrolyte concentration in the upper jejunum of normal man. Digestion 1983;26:218223.

    • Search Google Scholar
    • Export Citation
  • 12. Hyams JS, Treem WR, Etienne NL, et al. Effect of infant formula on stool characteristics of young infants. Pediatrics 1995;95:5054.

  • 13. Raditic DM, Remillard RL, Tater KC. ELISA testing for common food antigens in four dry dog foods used in dietary elimination trials. J Anim Physiol Anim Nutr (Berl) 2011;95:9097.

    • Search Google Scholar
    • Export Citation
  • 14. de-Oliveira LD, Takakura FS, Kienzle E, et al. Fibre analysis and fibre digestibility in pet foods—a comparison of total dietary fibre, neutral and acid detergent fibre and crude fibre. J Anim Physiol Anim Nutr (Berl) 2012;96:895906.

    • Search Google Scholar
    • Export Citation
  • 15. de Godoy MR, Kerr KR, Fahey. GC Jr. Alternative dietary fiber sources in companion animal nutrition. Nutrients 2013;5:30993117.

  • 16. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125:14011412.

    • Search Google Scholar
    • Export Citation
  • 17. Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients 2013;5:14171435.

  • 18. Swanson KS, Grieshop CM, Flickinger EA, et al. Supplemental fructooligosaccharides and mannanoligosaccharides influence immune function, ileal and total tract nutrient digestibilities, microbial populations and concentrations of protein catabolites in the large bowel of dogs. J Nutr 2002;132:980989.

    • Search Google Scholar
    • Export Citation
  • 19. Flickinger EA, Wolf BW, Garleb KA, et al. Glucose-based oligosaccharides exhibit different in vitro fermentation patterns and affect in vivo apparent nutrient digestibility and microbial populations in dogs. J Nutr 2000;130:12671273.

    • Search Google Scholar
    • Export Citation
  • 20. Strickling JH, Harmon DL, Dawson KA, et al. Evaluation of oligosaccharide addition to dog diets: influences on nutrient digestion and microbial populations. Anim Feed Sci Technol 2000;86:205219.

    • Search Google Scholar
    • Export Citation
  • 21. Zentek J, Marquart B, Pietrzak T, et al. Dietary effects on bifidobacteria and Clostridium perfringens in the canine intestinal tract. J Anim Physiol Anim Nutr (Berl) 2003;87:397407.

    • Search Google Scholar
    • Export Citation
  • 22. Swanson KS, Grieshop CM, Flickinger EA, et al. Fructooligosaccharides and Lactobacillus acidophilus modify bowel function and protein catabolites excreted by healthy humans. J Nutr 2002;132:30423050.

    • Search Google Scholar
    • Export Citation
  • 23. Zentek J, Meyer H. Normal handling of diets—are all dogs created equal? J Small Anim Pract 1995;36:354359.

  • 24. Meyer HK, Kienzle E, Zentek J. Body size and relative weights of gastrointestinal tract and liver in dogs. J Vet Nutr 1993;2:3135.

  • 25. Schunemann C, Mühlum A, Junker S, et al. Praecaecale und postileale verdaulichkeit verschiedener starken sowie pH-werte und gehalte an organischen sauren in darmchumus and faeces. Adv Anim Physiol Anim Nutr 1989;19:4458.

    • Search Google Scholar
    • Export Citation
  • 26. Dethioux F, Marniquet P, Petit P, et al. Importance of proteins together with soluble and insoluble fibers on a cat's digestive tolerance. Royal Canin Focus 2005;37–50.

    • Search Google Scholar
    • Export Citation
  • 27. Binder HS, Sandle GI. Electrolyte absorption and secretion in the mammalian colon. In: Johnson L, ed. Physiology of the gastrointestinal tract. 2nd ed. New York: Raven Press, 1987;13891418.

    • Search Google Scholar
    • Export Citation
  • 28. Rudinsky AJ, Howard JP, Bishop MA, et al. Dietary management of presumptive protein-losing enteropathy in Yorkshire Terriers. J Small Anim Pract 2017;58:103108.

    • Search Google Scholar
    • Export Citation
  • 29. Okanishi H, Yoshioka R, Kagawa Y, et al. The clinical efficacy of dietary fat restriction in treatment of dogs with intestinal lymphangiectasia. J Vet Intern Med 2014;28:809817.

    • Search Google Scholar
    • Export Citation
  • 30. Lewis LD, Boulay JP, Chow FHC. Fat excretion and assimilation by the cat. Feline Pract 1979;9:4649.

  • 31. Laflamme DP, Xu H, Long GM. Effect of diets differing in fat content on chronic diarrhea in cats. J Vet Intern Med 2011;25:230235.

  • 32. Michel KE. Unconventional diets for dogs and cats. Vet Clin North Am Small Anim Pract 2006;36:12691281, vi-vii.

  • 33. Stockman J, Fascetti AJ, Kass PH, et al. Evaluation of recipes of home-prepared maintenance diets for dogs. J Am Vet Med Assoc 2013;242:15001505.

    • Search Google Scholar
    • Export Citation
  • 34. Marks SL, Laflamme DP, McAloose D. Dietary trial using a commercial hypoallergenic diet containing hydrolyzed protein for dogs with inflammatory bowel disease. Vet Ther 2002;3:109118.

    • Search Google Scholar
    • Export Citation
  • 35. Mandigers PJ, Biourge V, van den Ingh TS, et al. A randomized, open-label, positively-controlled field trial of a hydrolyzed protein diet in dogs with chronic small bowel enteropathy. J Vet Intern Med 2010;24:13501357.

    • Search Google Scholar
    • Export Citation
  • 36. Walker D, Knuchel-Takano A, McCutchan A, et al. A comprehensive pathological survey of duodenal biopsies from dogs with diet-responsive chronic enteropathy. J Vet Intern Med 2013;27:862874.

    • Search Google Scholar
    • Export Citation
  • 37. Allenspach K, Culverwell C, Chan D. Long-term outcome in dogs with chronic enteropathies: 203 cases. Vet Rec 2016;178:368.

  • 38. Mandigers PJ, Biourge V, German AJ. Efficacy of a commercial hydrolysate diet in eight cats suffering from inflammatory bowel disease or adverse reaction to food. Tijdschr Diergeneeskd 2010;135:668672.

    • Search Google Scholar
    • Export Citation
  • 39. Luckschander N, Allenspach K, Hall J, et al. Perinuclear antineutrophilic cytoplasmic antibody and response to treatment in diarrheic dogs with food responsive disease or inflammatory bowel disease. J Vet Intern Med 2006;20:221227.

    • Search Google Scholar
    • Export Citation
  • 40. Sauter SN, Benyacoub J, Allenspach K, et al. Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet. J Anim Physiol Anim Nutr (Berl) 2006;90:269277.

    • Search Google Scholar
    • Export Citation
  • 41. Allenspach K, Wieland B, Grone A, et al. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med 2007;21:700708.

    • Search Google Scholar
    • Export Citation
  • 42. Guilford WG, Jones BR, Markwell PJ, et al. Food sensitivity in cats with chronic idiopathic gastrointestinal problems. J Vet Intern Med 2001;15:713.

    • Search Google Scholar
    • Export Citation
  • 43. Nelson RW, Dimperio ME, Long GG. Lymphocytic-plasmacytic colitis in the cat. J Am Vet Med Assoc 1984;184:11331135.

  • 44. Leib MS. Treatment of chronic idiopathic large-bowel diarrhea in dogs with a highly digestible diet and soluble fiber: a retrospective review of 37 cases. J Vet Intern Med 2000;14:2732.

    • Search Google Scholar
    • Export Citation
  • 45. Lecoindre P, Gaschen FP. Chronic idiopathic large bowel diarrhea in the dog. Vet Clin North Am Small Anim Pract 2011;41:447456.

  • 46. Dennis JS, Kruger JM, Mullaney TP. Lymphocytic/plasmacytic colitis in cats: 14 cases (1985–1990). J Am Vet Med Assoc 1993;202:313318.

    • Search Google Scholar
    • Export Citation
  • 47. Simpson JW, Maskell IE, Markwell PJ. Use of a restricted antigen diet in the management of idiopathic canine colitis. J Small Anim Pract 1994;35:234.

    • Search Google Scholar
    • Export Citation
  • 48. Laflamme DP, Xu H, Cupp CJ, et al. Evaluation of canned therapeutic diets for the management of cats with naturally occurring chronic diarrhea. J Feline Med Surg 2012;14:669677.

    • Search Google Scholar
    • Export Citation
  • 49. Erickson S. Dietary management of canine lymphangiectasia. Vet Med 1988;83:282286.

  • 50. Peterson PB, Willard MD. Protein-losing enteropathies. Vet Clin North Am Small Anim Pract 2003;33:10611082.

  • 51. Simmerson SM, Armstrong PJ, Wunschmann A, et al. Clinical features, intestinal histopathology, and outcome in protein-losing enteropathy in Yorkshire Terrier dogs. J Vet Intern Med 2014;28:331337.

    • Search Google Scholar
    • Export Citation
  • 52. Sherding RD. Canine intestinal lymphangiectasia, in Proceedings. 5th Annu Vet Med Forum Am Coll Vet Intern Med 1987;679682.

  • 53. Packey CD, Sartor RB. Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases. J Intern Med 2008;263:597606.

    • Search Google Scholar
    • Export Citation
  • 54. Münster M, Horauf A, Bilzer T. Assessment of disease severity and outcome of dietary, antibiotic, and immunosuppressive interventions by use of the canine IBD activity index in 21 dogs with chronic inflammatory bowel disease [in German]. Berl Munch Tierarztl Wochenschr 2006;119:493505.

    • Search Google Scholar
    • Export Citation
  • 55. Allenspach K, Vaden SL, Harris TS, et al. Evaluation of colonoscopic allergen provocation as a diagnostic tool in dogs with proven food hypersensitivity reactions. J Small Anim Pract 2006;47:2126.

    • Search Google Scholar
    • Export Citation
  • 56. Perea SC, Marks SL, Daristotle L, et al. Evaluation of two dry commercial therapeutic diets for the management of feline chronic gastroenteropathy. Front Vet Sci 2017;4:69.

    • Search Google Scholar
    • Export Citation
  • 57. Roudebush P, Guilford GW, Jackson HA. Chapter 31: adverse reactions to food. In: Hand MS, Thatcher CD, Remillard RL, et al, eds. Small animal clinical nutrition. 5th ed. Topeka, Kan: Mark Morris Institute, 2010;609635.

    • Search Google Scholar
    • Export Citation
  • 58. Ohmori K, Masuda K, Kawarai S, et al. Identification of bovine serum albumin as an IgE-reactive beef component in a dog with food hypersensitivity against beef. J Vet Med Sci 2007;69:865867.

    • Search Google Scholar
    • Export Citation
  • 59. Lehrer SB, Horner WE, Reese G. Why are some proteins allergenic? Implications for biotechnology. Crit Rev Food Sci Nutr 1996;36:553564.

    • Search Google Scholar
    • Export Citation
  • 60. Nguyen PG, Dumon HJ, Siliart BS, et al. Effects of dietary fat and energy on body weight and composition after gonadectomy in cats. Am J Vet Res 2004;65:17081713.

    • Search Google Scholar
    • Export Citation
  • 61. White SD. Food hypersensitivity in 30 dogs. J Am Vet Med Assoc 1986;188:695698.

  • 62. Jeffers JG, Meyer EK, Sosis EJ. Responses of dogs with food allergies to single-ingredient dietary provocation. J Am Vet Med Assoc 1996;209:608611.

    • Search Google Scholar
    • Export Citation
  • 63. Loeffler A, Soares-Magalhaes R, Bond R, et al. A retrospective analysis of case series using home-prepared and chicken hydrolysate diets in the diagnosis of adverse food reactions in 181 pruritic dogs. Vet Dermatol 2006;17:273279.

    • Search Google Scholar
    • Export Citation
  • 64. Roudebush P, McKeever PJ. Evaluation of a commercial canned lamb and rice diet for the management of cutaneous adverse reactions to foods in cats. Vet Dermatol 1993;4:14.

    • Search Google Scholar
    • Export Citation
  • 65. Frick OL. Pathogenesis of chronic allergic reactions using the atopic dog as a model, in Proceedings. Annu Meet Acad Vet Allergy 1991;7–10.

    • Search Google Scholar
    • Export Citation
  • 66. Jackson HA, Jackson MW, Coblentz L, et al. Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy. Vet Dermatol 2003;14:181187.

    • Search Google Scholar
    • Export Citation
  • 67. Guilford WG, Strombeck DR, Rogers Q, et al. Development of gastroscopic food sensitivity testing in dogs. J Vet Intern Med 1994;8:414422.

    • Search Google Scholar
    • Export Citation
  • 68. Puigdemont A, Brazís P, Serra M, et al. Immunologic responses against hydrolyzed soy protein in dogs with experimentally induced soy hypersensitivity. Am J Vet Res 2006;67:484488.

    • Search Google Scholar
    • Export Citation
  • 69. Serra M, Brazis P, Fondati A, et al. Assessment of IgE binding to native and hydrolyzed soy protein in serum obtained from dogs with experimentally induced soy protein hypersensitivity. Am J Vet Res 2006;67:18951900. PubMed

    • Search Google Scholar
    • Export Citation
  • 70. Ishida R, Masuda K, Kurata K, et al. Lymphocyte blastogenic responses to inciting food allergens in dogs with food hypersensitivity. J Vet Intern Med 2004;18:2530.

    • Search Google Scholar
    • Export Citation
  • 71. Dossin O, Lavoue R. Protein-losing enteropathies in dogs. Vet Clin North Am Small Anim Pract 2011;41:399418.

  • 72. Jeffries GH, Chapman A, Sleisenger MH. Low-fat diet in intestinal lymphangiectasia. Its effect on albumin metabolism. N Engl J Med 1964;270:761766.

    • Search Google Scholar
    • Export Citation
  • 73. Simmonds WJ. The effect of fluid, electrolyte and food intake on thoracic duct lymph flow in unanaesthetized rats. Aust J Exp Biol Med Sci 1954;32:285299.

    • Search Google Scholar
    • Export Citation
  • 74. Finco DR, Duncan JR, Schall WD, et al. Chronic enteric disease and hypoproteinemia in 9 dogs. J Am Vet Med Assoc 1973;163:262271.

  • 75. Mattheuws D, De Rick A, Thoonen H, et al. Intestinal lymphangiectasia in a dog. J Small Anim Pract 1974;15:757761.

  • 76. Tams TT, Twedt DC. Canine protein-losing gastroenteropathy syndrome. Compend Contin Educ Vet 1981;3:105118.

  • 77. Hall EJ, Batt RM. Dietary modulation of gluten sensitivity in a naturally occurring enteropathy of Irish Setter dogs. Gut 1992;33:198205.

    • Search Google Scholar
    • Export Citation
  • 78. Hall EJ, Batt RM. Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish Setter dogs. Gut 1991;32:749753.

    • Search Google Scholar
    • Export Citation
  • 79. Hall EJ, Batt RM. Development of wheat-sensitive enteropathy in Irish Setters: morphologic changes. Am J Vet Res 1990;51:978982.

  • 80. Hall EJ, Batt RM. Development of wheat-sensitive enteropathy in Irish Setters: biochemical changes. Am J Vet Res 1990;51:983989.

  • 81. Lowrie M, Hadjivassiliou M, Sanders DS, et al. A presumptive case of gluten sensitivity in a Border Terrier: a multisystem disorder? Vet Rec 2016;179:573.

    • Search Google Scholar
    • Export Citation
  • 82. Lowrie M, Garden OA, Hadjivassiliou M, et al. The clinical and serological effect of a gluten-free diet in Border Terriers with epileptoid cramping syndrome. J Vet Intern Med 2015;29:15641568.

    • Search Google Scholar
    • Export Citation
  • 83. Nelson RW, Stookey LJ, Kazacos E. Nutritional management of idiopathic chronic colitis in the dog. J Vet Intern Med 1988;2:133137.

  • 84. Simpson JW. Management of colonic disease in the dog. Waltham Focus 1995;5:1722.

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Nutritional management of chronic enteropathies in dogs and cats

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  • 1 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
  • | 2 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.
  • | 3 Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210.

Contributor Notes

Address correspondence to Dr. Rudinsky (rudinsky.3@osu.edu).