Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
ISSN:
0003-1488
Publication Date:
01 Mar 2017

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Cardiac findings in Quarter Horses with heritable equine regional dermal asthenia

Erin L. Brinkman DVM1, Benjamin C. Weed PhD2, Sourav S. Patnaik PhD3, Bryn L. Brazile PhD4, Ryan M. Centini DVM5, Robert W. Wills DVM, PhD6, Bari Olivier DVM, PhD7, Dodd G. Sledge DVM, PhD8, Jim Cooley DVM9, Jun Liao PhD10, and Ann M. Rashmir-Raven DVM11
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  • 1 Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 2 Department of Agricultural and Biological Engineering, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 3 Department of Agricultural and Biological Engineering, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 4 Department of Agricultural and Biological Engineering, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 5 Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 6 Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 7 Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824.
  • | 8 Diagnostic Center for Population and Animal Health, Michigan State University, East Lansing, MI 48824.
  • | 9 Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 10 Department of Agricultural and Biological Engineering, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762.
  • | 11 Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824.
DOI:
https://doi.org/10.2460/javma.250.5.538
Volume/Issue:
Volume 250: Issue 5
Online Publication Date:
01 Mar 2017
Restricted access
Reprints and Permissions Purchase Article

Abstract

OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA).

DESIGN Prospective case-control study.

ANIMALS 41 Quarter Horses.

PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses. Echocardiography was performed in 14 HERDA-affected and 11 control horses. Biomechanical data and echocardiographic variables of interest were compared between groups by statistical analyses,

RESULTS Mean values for mean and maximum UTS of heart valves were significantly lower in HERDA-affected horses than in controls. Blood vessels were identified in aortic valve leaflets of HERDA-affected but not control horses. Most echocardiographic data did not differ between groups. When the statistical model for echocardiographic measures was controlled for body weight, mean and maximum height and width of the aorta at the valve annulus in short-axis images were significantly associated with HERDA status and were smaller for affected horses.

CONCLUSIONS AND CLINICAL RELEVANCE Lower UTS of heart valves in HERDA-affected horses, compared with those of control horses, supported that tissues other than skin with high fibrillar collagen content are abnormal in horses with HERDA. Lack of significant differences in most echocardiographic variables between affected and control horses suggested that echocardiography may not be useful to detect a substantial loss of heart valve tensile strength. Further investigation is warranted to confirm these findings. Studies in horses with HERDA may provide insight into cardiac abnormalities in people with collagen disorders.

Abstract

OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA).

DESIGN Prospective case-control study.

ANIMALS 41 Quarter Horses.

PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses. Echocardiography was performed in 14 HERDA-affected and 11 control horses. Biomechanical data and echocardiographic variables of interest were compared between groups by statistical analyses,

RESULTS Mean values for mean and maximum UTS of heart valves were significantly lower in HERDA-affected horses than in controls. Blood vessels were identified in aortic valve leaflets of HERDA-affected but not control horses. Most echocardiographic data did not differ between groups. When the statistical model for echocardiographic measures was controlled for body weight, mean and maximum height and width of the aorta at the valve annulus in short-axis images were significantly associated with HERDA status and were smaller for affected horses.

CONCLUSIONS AND CLINICAL RELEVANCE Lower UTS of heart valves in HERDA-affected horses, compared with those of control horses, supported that tissues other than skin with high fibrillar collagen content are abnormal in horses with HERDA. Lack of significant differences in most echocardiographic variables between affected and control horses suggested that echocardiography may not be useful to detect a substantial loss of heart valve tensile strength. Further investigation is warranted to confirm these findings. Studies in horses with HERDA may provide insight into cardiac abnormalities in people with collagen disorders.

Contributor Notes

Dr. Weed's present address is LabAnswer Center of Excellence, 9102 Southpark Center Loop #200, Orlando, FL 32819.

Dr. Patnaik's present address is Vascular Biomechanics and Biofluids Laboratory, 1 UTSA Cir, San Antonio, TX 78249.

Dr. Brazile's present address is Eye and Ear Institute, 203 Lothrop St, Pittsburgh, PA 15206.

Dr. Centini's present address is Department of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195.

Dr. Liao's present address is Department of Bioengineering, College of Engineering, University of Texas at Arlington, Arlington, TX 76010.

Address correspondence to Dr. Brinkman (brinkman@cvm.msstate.edu).