Rabies is a fatal viral zoonosis and a serious public health problem.1 The disease is an acute progressive encephalitis caused by a Lyssavirus. Multiple viral variants are maintained in wild mammal populations in the United States. All mammals are believed to be susceptible to the disease, and for purposes of this document, use of the term “animal” refers to mammals. The recommendations in this compendium serve as a basis for animal rabies prevention and control programs throughout the United States and facilitate standardization of procedures among jurisdictions, thereby contributing to an effective national rabies control program. This document is reviewed annually and revised as necessary. These recommendations do not supersede state and local laws or requirements. Principles of rabies prevention and control are detailed in Part I; Part II contains recommendations for parenteral vaccination procedures; all animal rabies vaccines licensed by the USDA and marketed in the United States are listed in Part III.
Rabies. In:Heymann D, ed.Control of communicable diseases manual. 18th ed. Washington, DC: American Public Health Association, 2004:438–447.
CDC. Human rabies prevention—United States, 1999. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 1999;48:(No. RR-1).
Blanton JD, Krebs JW, Hanlon CA, et al. Rabies surveillance in the United States during 2005. J Am Vet Med Assoc 2006;229:1897–1911.
McQuiston J, Yager PA, Smith JS, et al. Epidemiologic characteristics of rabies virus variants in dogs and cats in the United States, 1999. J Am Vet Med Assoc 2001;218:1939–1942.
Hanlon CA, Childs JE, Nettles VF, et al. Recommendations of the Working Group on Rabies. Article III: rabies in wildlife. National Working Group on Rabies Prevention and Control. J Am Vet Med Assoc 1999;215:1612–1618.
Hanlon CA, Smith JS, Anderson GR, et al. Recommendations of the Working Group on Rabies. Article II: laboratory diagnosis of rabies. National Working Group on Rabies Prevention and Control. J Am Vet Med Assoc 1999;215:1444–1446.
Rudd RJ, Smith JS, Yager PA, et al. A need for standardized rabies-virus diagnostic procedures: effect of cover-glass mountant on the reliability of antigen detection by the fluorescent antibody test. Virus Res 2005;111:83–88.
Rabies and other lyssavirus infections. In: Greene CE, ed.Infectious diseases of the dog and cat. 3rd ed. New York: Saunders Elsevier, 2006;167–183.
Rupprecht CE, Gilbert J, Pitts R, et al. Evaluation of an inactivated rabies virus vaccine in domestic ferrets. J Am Vet Med Assoc 1990;196:1614–1616.
National Association of State Public Health Veterinarians. Compendium of measures to prevent disease and injury associated with animals in public settings, 2006. Available at: www.nasphv.org. Accessed Dec 1, 2006.
Bender J, Schulman S. Reports of zoonotic disease outbreaks associated with animal exhibits and availability of recommendations for preventing zoonotic disease transmission from animals to people in such settings. J Am Vet Med Assoc 2004;224:1105–1109.
Private ownership of wild animals. Available at: www.avma.org/issues/policy/wild_animal_ownership.asp. Accessed Dec 1, 2006.
Hanlon CA, Niezgoda MN, Rupprecht CE. Postexposure prophylaxis for prevention of rabies in dogs. Am J Vet Res 2002;63:1096–1100.
Charlton KM. The pathogenesis of rabies and other lyssaviral infections: recent studies. Curr Top Microbiol Immunol 1994;187:95–119.
CDC. Mass treatment of humans who drank unpasteurized milk from rabid cows—Massachusetts, 1996–1998. MMWR Morb Mortal Wkly Rep 1999;48:228–229.
Niezgoda M, Briggs DJ, Shaddock J, et al. Viral excretion in domestic ferrets (Mustela putorius furo) inoculated with a raccoon rabies isolate. Am J Vet Res 1998;59:1629–1632.
Tepsumethanon V, Lumlertdacha B, Mitmoonpitak C, et al. Survival of naturally infected rabid dogs and cats. Clin Infect Dis 2004;39:278–280.
Rupprecht CE, Smith JS, Fekadu M, et al. The ascension of wildlife rabies: a cause for public health concern or intervention? Emerg Infect Dis 1995;1:107–114.
Krebs JW, Strine TW, Smith JS, et al. Rabies surveillance in the United States during 1993. J Am Vet Med Assoc 1994;205:1695–1709.
Engeman RM, Christensen KL, Pipas MJ, et al. Population monitoring in support of a rabies vaccination program for skunks in Arizona. J Wildl Dis 2003;39:746–750.
The Humane Society of the United States. HSUS Disaster Services. Available at: www.hsus.org/hsus_field/hsus_disaster_center/. Accessed Dec 1, 2006.
Slate D, Rupprecht CE, Rooney JA, et al. Status of oral rabies vaccination in wild carnivores in the United States. Virus Res 2005;111:68–76.
Messenger SL, Smith JS, Rupprecht CE. Emerging epidemiology of bat-associated cryptic cases of rabies in humans in the United States. Clin Infect Dis 2002;35:738–747.
Frantz SC, Trimarchi CV. Bats in human dwellings: health concerns and management. In:Decker DF, ed.Proceedings of the first eastern wildlife damage control conference. Ithaca, NY: Cornell University Press, 1983;299–308.
Bunn TO. Canine and feline vaccines, past and present. In:Baer GM, ed.The natural history of rabies. 2nd ed. Boca Raton, Fla: CRC Press, 1991;415–425.
Gobar GM, Kass PH. World Wide Web-based survey of vaccination practices, postvaccinal reactions, and vaccine site-associated sarcomas in cats. J Am Vet Med Assoc 2002;220:1477–1482.
Macy DW, Hendrick MJ. The potential role of inflammation in the development of postvaccinal sarcomas in cats. Vet Clin North Am Small Anim Pract 1996;26:103–109.
Rupprecht CE, Blass L, Smith K, et al. Human infection due to recombinant vaccinia-rabies glycoprotein virus. N Engl J Med 2001;345:582–586.
Rabies vaccine manufacturer contact information.
|Manufacturer||Phone number||Internet address|
|Fort Dodge Animal Health||800-533-8536||www.wyeth.com/divisions/fort_dodge.asp|