Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
ISSN:
0003-1488
Publication Date:
15 Jan 2006
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Serum alkaline phosphatase activity in Scottish Terriers versus dogs of other breeds

Derek D. Nestor DVM, DACVIM1, Kate M. Holan DVM, DACVIM2, Cheri A. Johnson DVM, MS, DACVIM3, William Schall DVM, MS, DACVIM4, and John B. Kaneene DVM, MPH, PhD5
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  • 1 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823.
  • | 2 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823.
  • | 3 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823.
  • | 4 Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823.
  • | 5 Population Medicine Center, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48823.
DOI:
https://doi.org/10.2460/javma.228.2.222
Volume/Issue:
Volume 228: Issue 2
Online Publication Date:
15 Jan 2006
Restricted access
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Abstract

Objective—To determine whether Scottish Terriers have higher serum alkaline phosphatase (ALP) activities and a higher prevalence of diseases commonly associated with high serum ALP activity than do dogs of other breeds.

Design—Retrospective case-control study.

Animals—85 Scottish Terriers and 340 age-matched control dogs that were not Scottish Terriers.

Procedure—Medical records were reviewed, and data for year of evaluation, age, sex, breed, serum ALP activity, and final diagnosis were recorded.

Results—Scottish Terriers had a significantly higher mean serum ALP activity than did control dogs (1,520 U/L vs 306 U/L). Regardless of breed, dogs that had a disease commonly associated with high serum ALP activity had a significantly higher mean serum ALP activity than did dogs without such diseases (1,304 U/L vs 427 U/L). Scottish Terriers were 2.4 times as likely to have a disease commonly associated with high serum ALP activity than were control dogs, but Scottish Terriers with diseases commonly associated with high serum ALP activity had a significantly higher mean ALP activity than did control dogs with such diseases (2,073 U/L vs 909 U/L), and Scottish Terriers without such diseases had a significantly higher mean serum ALP activity than did control dogs without such diseases (1,349 U/L vs 228 U/L).

Conclusions and Clinical Relevance—Results suggest that Scottish Terriers have higher serum ALP activities than do dogs of other breeds. Although Scottish Terriers also have a higher prevalence of diseases associated with high serum ALP activity, this alone did not explain the higher mean serum ALP activity in the breed.

Abstract

Objective—To determine whether Scottish Terriers have higher serum alkaline phosphatase (ALP) activities and a higher prevalence of diseases commonly associated with high serum ALP activity than do dogs of other breeds.

Design—Retrospective case-control study.

Animals—85 Scottish Terriers and 340 age-matched control dogs that were not Scottish Terriers.

Procedure—Medical records were reviewed, and data for year of evaluation, age, sex, breed, serum ALP activity, and final diagnosis were recorded.

Results—Scottish Terriers had a significantly higher mean serum ALP activity than did control dogs (1,520 U/L vs 306 U/L). Regardless of breed, dogs that had a disease commonly associated with high serum ALP activity had a significantly higher mean serum ALP activity than did dogs without such diseases (1,304 U/L vs 427 U/L). Scottish Terriers were 2.4 times as likely to have a disease commonly associated with high serum ALP activity than were control dogs, but Scottish Terriers with diseases commonly associated with high serum ALP activity had a significantly higher mean ALP activity than did control dogs with such diseases (2,073 U/L vs 909 U/L), and Scottish Terriers without such diseases had a significantly higher mean serum ALP activity than did control dogs without such diseases (1,349 U/L vs 228 U/L).

Conclusions and Clinical Relevance—Results suggest that Scottish Terriers have higher serum ALP activities than do dogs of other breeds. Although Scottish Terriers also have a higher prevalence of diseases associated with high serum ALP activity, this alone did not explain the higher mean serum ALP activity in the breed.

Contributor Notes

Address correspondence to Dr. Nestor.

Dr. Nestor's present address is Animal Emergency and Referral Center of Central Iowa, 6110 Creston Ave, Des Moines, IA 50321.