Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
ISSN:
0003-1488
Publication Date:
15 Jan 2006
  • 1

    Thamm DH, Vail DM. Mast cell tumors. In: Withrow SJ, MacEwan EG, eds. Small animal clinical oncology. 3rd ed. Philadelphia: WB Saunders Co, 2001; 261–282.

    • Search Google Scholar
    • Export Citation
  • 2

    Macy DW. Canine and feline mast cell tumors: biologic behavior, diagnosis, and therapy. Semin Vet Med Surg (Small Anim) 1986; 1: 72–83.

    • Search Google Scholar
    • Export Citation
  • 3

    Rogers KS. Mast cell tumors: dilemmas of diagnosis and treatment. Vet Clin North Am Small Anim Pract 1996; 26: 87–102.

  • 4

    Simoes JPC, Shoning P, Butine M. Prognosis of canine mast cell tumors: a comparison of three methods. Vet Pathol 1994; 31: 637–647.

  • 5

    Strefezzi R de F, Xavier JG, Catao-Dias JL. Morphometry of canine cutaneous mast cell tumors. Vet Pathol 2003; 40: 268–275.

  • 6

    Seguin B, Leibman NF, Bregazzi VS, et al.Clinical outcome of dogs with grade-II mast cell tumors treated with surgery alone: 55 cases (1996–1999). J Am Vet Med Assoc 2001; 218: 1120–1123.

    • Search Google Scholar
    • Export Citation
  • 7

    Turrel JM, Kitchell BE, Miller LM, et al.Prognostic factors for radiation treatment of mast cell tumor in 85 dogs. J Am Vet Med Assoc 1988; 193: 936–940.

    • Search Google Scholar
    • Export Citation
  • 8

    Bostock DE. The prognosis following surgical removal of mastocytomas in dogs. J Small Anim Pract 1973; 14: 27–40.

  • 9

    O'Keefe DA. Canine mast cell tumors. Vet Clin North Am Small Anim Pract 1990; 20: 1105–1115.

  • 10

    Hottendorf GH, Nielsen SW. Pathologic report of 29 necropsies on dogs with mastocytoma. Vet Pathol 1968; 5: 102–121.

  • 11

    Michels GM, Knapp DW, DeNicola DB, et al.Prognosis following surgical excision of canine cutaneous mast cell tumors with histopathologically tumor-free versus nontumor-free margins: a retrospective study of 31 cases. J Am Anim Hosp Assoc 2002; 38: 458–466.

    • Search Google Scholar
    • Export Citation
  • 12

    Jaffe MH, Hosgood G, Taylor HW, et al.Immunohistochemical and clinical evaluation of p53 in canine cutaneous mast cell tumors. Vet Pathol 2000; 37: 40–46.

    • Search Google Scholar
    • Export Citation
  • 13

    Geiger TL, Theon AP, Werner JA, et al.Biologic behavior and prognostic factors for mast cell tumors of the canine muzzle: 24 cases (1990–2001). J Vet Intern Med 2003; 17: 687–692.

    • Search Google Scholar
    • Export Citation
  • 14

    Ginn PE, Fox LE, Brower JC, et al.Immunohistochemical detection of p53 tumor-suppressor protein is a poor indicator of prognosis for canine cutaneous mast cell tumors. Vet Pathol 2000; 37: 33–39.

    • Search Google Scholar
    • Export Citation
  • 15

    Ishiguro T, Kadosawa T, Takagi S, et al.Relationship of disease progression and plasma histamine concentrations in 11 dogs with mast cell tumors. J Vet Intern Med 2003; 17: 194–198.

    • Search Google Scholar
    • Export Citation
  • 16

    O'Keefe DA, Couto CG, Burke-Schwartz C, et al. Systemic mastocytosis in 16 dogs. J Vet Intern Med 1987; 1: 75–80.

  • 17

    Patnaik AK, Ehler WJ, MacEwan EG. Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Vet Pathol 1984; 21: 469–474.

    • Search Google Scholar
    • Export Citation
  • 18

    Abadie JJ, Amardeilh MA, Delverdier ME. Immunohistochemical detection of proliferating cell nuclear antigen and Ki-67 in mast cell tumors from dogs. J Am Vet Med Assoc 1999; 215: 1629–1934.

    • Search Google Scholar
    • Export Citation
  • 19

    McCaw DL, Miller MA, Bergman PJ, et al. Vincristine therapy for mast cell tumors in dogs. J Vet Intern Med 1997; 11: 375–378.

  • 20

    Simpson AM, Ludwig LL, Newman SJ, et al.Evaluation of surgical margins required for complete excision of cutaneous mast cell tumors in dogs. J Am Vet Med Assoc 2004; 224: 236–240.

    • Search Google Scholar
    • Export Citation
  • 21

    Weisse C, Shofer FS, Sorenmo K. Recurrence rates and sites for grade II canine cutaneous mast cell tumors following surgical excision. J Am Anim Hosp Assoc 2002; 38: 71–73.

    • Search Google Scholar
    • Export Citation
  • 22

    Cahalane AK, Payne S, Barber LG, et al.Prognostic factors for survival of dogs with inguinal and perineal mast cell tumors treated surgically with or without adjunctive treatment: 68 cases (1994–2002). J Am Vet Med Assoc 2004; 224: 401–408.

    • Search Google Scholar
    • Export Citation
  • 23

    Murphy S, Sparkes AH, Smith KC, et al.Relationships between the histological grade of cutaneous mast cell tumours in dogs, their survival and the efficacy of surgical resection. Vet Rec 2004; 154: 743–746.

    • Search Google Scholar
    • Export Citation
  • 24

    Powers BE. The pathology of neoplasia. In: Withrow SJ, MacEwan EG, eds. Small animal clinical oncology. 2nd ed. Philadelphia: WB Saunders Co, 1996; 4–15.

    • Search Google Scholar
    • Export Citation
  • 25

    Leibman NF, Lana SE, Hansen RA, et al.Identification of matrix metalloproteinases in canine cutaneous mast cell tumors. J Vet Intern Med 2000; 14: 583–586.

    • Search Google Scholar
    • Export Citation
  • 26

    Brennan JA, Mao L, Hruban RH, et al.Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. N Engl J Med 1995; 332: 429–435.

    • Search Google Scholar
    • Export Citation
  • 27

    Gamblin RM, Sagartz JE, Couto CG. Overexpression of p53 tumor suppressor protein in spontaneously arising neoplasms of dogs. Am J Vet Res 1997; 58: 857–863.

    • Search Google Scholar
    • Export Citation
  • 28

    Kravis LD, Vail DM, Kisseberth WC, et al.Frequency of argyrophilic nucleolar organizer regions in fine-needle aspirates and biopsy specimens from mast cell tumors in dogs. J Am Vet Med Assoc 1996; 209: 1418–1420.

    • Search Google Scholar
    • Export Citation
  • 29

    Zavodovskaya R, Chien MB, London CA. Use of kit internal tandem duplications to establish mast cell tumor clonality in 2 dogs. J Vet Intern Med 2004; 18: 915–917.

    • Search Google Scholar
    • Export Citation

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Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs

Ryan P. Fulcher DVM1, Lori L. Ludwig VMD, MS, DACVS2, Philip J. Bergman DVM, PhD, DACVIM3, Shelley J. Newman DVM, DVSc, DACVP4, Amelia M. Simpson DVM, DACVS5, and Amiya K. Patnaik DVM, MS6
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  • 1 Department of Surgery, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.
  • | 2 Department of Surgery, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.
  • | 3 Donaldson-Atwood Cancer Clinic & Flaherty Comparative Oncology Laboratory, Department of Medicine, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.
  • | 4 Department of Pathology, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.
  • | 5 Department of Surgery, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.
  • | 6 Department of Pathology, The Animal Medical Center, 510 E 62nd St, New York, NY 10021.
DOI:
https://doi.org/10.2460/javma.228.2.210
Volume/Issue:
Volume 228: Issue 2
Online Publication Date:
15 Jan 2006
Restricted access
Reprints and Permissions Purchase Article

Abstract

Objective—To evaluate completeness of excision and clinical outcome in dogs with cutaneous mast cell tumors (MCTs) excised with a lateral margin of 2 cm and a deep margin of 1 fascial plane.

Design—Prospective study.

Animals—16 client-owned dogs with 1 or more cutaneous MCTs.

Procedure—Excision of MCTs was performed with a 2-cm lateral margin and a deep margin of 1 fascial plane. Histologic tumor grading was performed; surgical margins were categorized as complete or incomplete. Follow-up information was obtained via repeat examination of the dogs by veterinarians or client-completed questionnaires.

Results—4 grade I and 19 grade II cutaneous MCTs were evaluated. Overall, 21 (91%) MCTs were completely excised; 2 grade II tumors had foci of mast cells at the 2-cm margin. Two dogs received adjunctive treatments following surgery. Follow-up information was available for all dogs (median follow-up period, 379 days; range, 51 to 538 days); no local recurrence was detected during this time. De novo MCTs were detected in 3 of 16 dogs at 37, 54, and 154 days after surgery. Via Kaplan-Meier analysis, median survival time and disease-free interval were both > 538 days (medians not yet reached). No prognostic variables were identified.

Conclusions and Clinical Relevance—Excision with a 2-cm lateral margin and a deep margin of 1 fascial plane may result in satisfactory excision of grades I and II MCTs in dogs, with recurrence rates similar to those reported previously. Use of these margins may minimize complications associated with larger local tumor resection.

Abstract

Objective—To evaluate completeness of excision and clinical outcome in dogs with cutaneous mast cell tumors (MCTs) excised with a lateral margin of 2 cm and a deep margin of 1 fascial plane.

Design—Prospective study.

Animals—16 client-owned dogs with 1 or more cutaneous MCTs.

Procedure—Excision of MCTs was performed with a 2-cm lateral margin and a deep margin of 1 fascial plane. Histologic tumor grading was performed; surgical margins were categorized as complete or incomplete. Follow-up information was obtained via repeat examination of the dogs by veterinarians or client-completed questionnaires.

Results—4 grade I and 19 grade II cutaneous MCTs were evaluated. Overall, 21 (91%) MCTs were completely excised; 2 grade II tumors had foci of mast cells at the 2-cm margin. Two dogs received adjunctive treatments following surgery. Follow-up information was available for all dogs (median follow-up period, 379 days; range, 51 to 538 days); no local recurrence was detected during this time. De novo MCTs were detected in 3 of 16 dogs at 37, 54, and 154 days after surgery. Via Kaplan-Meier analysis, median survival time and disease-free interval were both > 538 days (medians not yet reached). No prognostic variables were identified.

Conclusions and Clinical Relevance—Excision with a 2-cm lateral margin and a deep margin of 1 fascial plane may result in satisfactory excision of grades I and II MCTs in dogs, with recurrence rates similar to those reported previously. Use of these margins may minimize complications associated with larger local tumor resection.

Contributor Notes

Address correspondence to Dr. Fulcher.

Dr. Fulcher's present address is Garden State Veterinary Specialists, Tinton Falls, NJ 07753.

Dr. Ludwig's present address is Veterinary Surgical Associates, Mount Pleasant, SC 29464.

Dr. Newman's present address is Department of Pathology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996-4542.

Dr. Simpson's present address is Veterinary Hospital University of Pennsylvania, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010.

†Deceased.