Neoplastic disease in dogs that are examined because of osteosarcoma is often staged on the basis of 3-view thoracic radiographic imaging (left, right lateromedial, and ventrodorsal radiographic views of the thorax) and nuclear scintigraphy to rule out the presence of gross metastases prior to initiating treatment. Approximately 10% of dogs have gross pulmonary or bone metastases at the time of initial examination. The diagnosis of osteosarcoma with metastatic disease is associated with a grave prognosis. We observed that certain dogs with metastatic disease lived longer than expected with aggressive treatment; the decision to initiate treatment was often made at the owner's request, despite the poor odds of survival. The purpose of the study reported here was to assess survival times in dogs in which a diagnosis of stage III osteosarcoma was made at the time of initial examination and that underwent treatment and to determine prognostic factors for improved survival times in affected dogs.
Nonsteroidal anti-inflammatory drug
SPSS, version 11.0, SPSS Inc, Chicago, Ill.
Meyers P, Heller G, Healey JH, et al. Osteogenic sarcoma with clinically detectable metastasis at initial presentation. J Clin Oncol 1993;11:449–453.
Kager L, Zoubek A, Pötschger U, et al. Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 2003;21:2011–2018.
Bacci G, Picci P, Ferrari S, et al. Synchronous multifocal osteosarcoma: results in twelve patients treated with neoadjuvant chemotherapy and simultaneous resection of all involved bones. Ann Oncol 1996;7:864–866.
Tsunemi T, Nagoya S, Kaya M, et al. Postoperative progression of pulmonary metastasis and osteosarcoma. Clin Orthop Relat Res 2003;407:159–166.
Kaya M, Wada T, Nagoya S, et al. Concomitant tumour resistance in patients with osteosarcoma. A clue to a new therapeutic strategy. J Bone Joint Surg Br 2004;86:143–147.
Bacci G, Mercuri M, Briccoli A, et al. Osteogenic sarcoma of the extremity with detectable lung metastases at presentation. Cancer 1997;79:245–254.
Picci P, Vanel D, Briccoli A, et al. Computed tomography of pulmonary metastases from osteosarcoma: the less poor technique. A study of 51 patients with histological correlation. Ann Oncol 2001;12:1601–1604.
Vanel D, Henry-Amar M, Lumbroso J, et al. Pulmonary evaluation of patients with osteosarcoma: roles of standard radiography, tomography, CT, scintigraphy and tomoscintigraphy. AJR Am J Roentgenol 1984;143:519–523.
Chalmers N, Best JJK. The significance of pulmonary nodules detected by CT but not by chest radiography in tumour staging. Clin Radiol 1991;44:410–412.