Clinical differentiation of acute necrotizing from chronic nonsuppurative pancreatitis in cats: 63 cases (1996–2001)

Jean A. Ferreri Department of Clinical Studies—Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Present address is The Center for Specialized Veterinary Care, 609- 5 Cantiaque Rock Rd, Westbury, NY 11590.

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 DVM
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Erin Hardam Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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Susan E. Kimmel Department of Clinical Studies—Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Present address is The Center for Specialized Veterinary Care, 609- 5 Cantiaque Rock Rd, Westbury, NY 11590.

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 DVM, DACVIM
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H. Mark Saunders Department of Clinical Studies—Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Present address is 148 Cheesefactory Ln, Shelburne, VT 05482.

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Thomas J. Van Winkle Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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Kenneth J. Drobatz Department of Clinical Studies—Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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Robert J. Washabau Department of Clinical Studies—Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104.

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 VMD, PhD, DACVIM

Abstract

Objective—To characterize clinical, clinicopathologic, radiographic, and ultrasonographic findings in cats with histologically confirmed acute necrotizing pancreatitis (ANP) or chronic nonsuppurative pancreatitis (CP) and identify features that may be useful in the antemortem differentiation of these disorders.

Design—Retrospective study.

Animals—63 cats with histologically confirmed ANP (n = 30) or CP (33).

Procedure—Medical records were reviewed for signalment, clinical signs, concurrent diseases, clinicopathologic findings, and results of radiography and ultrasonography.

Results—Cats in both groups had similar nonspecific clinical signs, physical examination findings, and radiographic and ultrasonographic abnormalities. Abdominal ultrasonographic abnormalities, including hypoechoic pancreas, hyperechoic mesentery, and abdominal effusion, were found in cats in both groups and, therefore, were not specific for ANP. Cats with CP were significantly more likely to have concurrent diseases than were cats with ANP (100 and 83%, respectively). Clinicopathologic abnormalities were similar between groups; however, serum alanine aminotransferase and alkaline phosphatase activities were significantly higher in cats with CP.

Conclusions and Clinical Relevance—Results suggest that ANP and CP in cats cannot be distinguished from each other solely on the basis of history, physical examination findings, results of clinicopathologic testing, radiographic abnormalities, or ultrasonographic abnormalities. (J Am Vet Med Assoc 2003;223:469–474)

Abstract

Objective—To characterize clinical, clinicopathologic, radiographic, and ultrasonographic findings in cats with histologically confirmed acute necrotizing pancreatitis (ANP) or chronic nonsuppurative pancreatitis (CP) and identify features that may be useful in the antemortem differentiation of these disorders.

Design—Retrospective study.

Animals—63 cats with histologically confirmed ANP (n = 30) or CP (33).

Procedure—Medical records were reviewed for signalment, clinical signs, concurrent diseases, clinicopathologic findings, and results of radiography and ultrasonography.

Results—Cats in both groups had similar nonspecific clinical signs, physical examination findings, and radiographic and ultrasonographic abnormalities. Abdominal ultrasonographic abnormalities, including hypoechoic pancreas, hyperechoic mesentery, and abdominal effusion, were found in cats in both groups and, therefore, were not specific for ANP. Cats with CP were significantly more likely to have concurrent diseases than were cats with ANP (100 and 83%, respectively). Clinicopathologic abnormalities were similar between groups; however, serum alanine aminotransferase and alkaline phosphatase activities were significantly higher in cats with CP.

Conclusions and Clinical Relevance—Results suggest that ANP and CP in cats cannot be distinguished from each other solely on the basis of history, physical examination findings, results of clinicopathologic testing, radiographic abnormalities, or ultrasonographic abnormalities. (J Am Vet Med Assoc 2003;223:469–474)

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