Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs

J. Catharine Scott-Moncrieff Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by J. Catharine Scott-Moncrieff in
Current site
Google Scholar
PubMed
Close
 Vet MB, MS, DACVIM
,
Juan Azcona-Olivera Department of Veterinary Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by Juan Azcona-Olivera in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Nita W. Glickman Department of Veterinary Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by Nita W. Glickman in
Current site
Google Scholar
PubMed
Close
 MS, MPH
,
Lawrence T. Glickman Department of Veterinary Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by Lawrence T. Glickman in
Current site
Google Scholar
PubMed
Close
 VMD, DrPH
, and
Harm HogenEsch Department of Veterinary Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.

Search for other papers by Harm HogenEsch in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Abstract

Objective—To determine whether routine vaccination induces antibodies against bovine thyroglobulin and autoantibodies against canine thyroglobulin in dogs.

Design—Prospective study.

Animals—20 healthy research Beagles and 16 healthy pet dogs.

Procedure—For the research Beagles, 5 dogs were vaccinated with a multivalent vaccine and a rabies vaccine, 5 dogs received only the multivalent vaccine, 5 dogs received only the rabies vaccine, and 5 dogs were unvaccinated controls. The multivalent vaccine was administered at 8, 10, 12, 16, 20, 26, and 52 weeks of age and every 6 months thereafter. The rabies vaccine was administered at 16 and 52 weeks of age and then once per year. Blood was collected from all dogs at 8, 16, and 26 weeks of age and then 4 times yearly. Assays for antibodies directed against bovine and canine thyroglobulin were performed prior to and 2 weeks after each yearly vaccination. For the pet dogs, blood was collected prior to and 2 weeks after 1 vaccination.

Results—In the research Beagles, there was a significant increase in anti-bovine thyroglobulin antibodies in all vaccinated dogs, compared with control dogs. There was a significant increase in anti-canine thyroglobulin antibodies in the 2 groups of dogs that received the rabies vaccine but not in the group that received the multivalent vaccine alone. In the pet dogs, there was a significant increase in anti-canine thyroglobulin antibodies after vaccination but no significant change in anti-bovine thyroglobulin antibodies.

Conclusions and Clinical Relevance—Recent vaccination may result in increased anti-canine thyroglobulin antibodies. Whether these antibodies have a deleterious effect on canine thyroid function is unknown. (J Am Vet Med Assoc 2002;221:515–521)

Abstract

Objective—To determine whether routine vaccination induces antibodies against bovine thyroglobulin and autoantibodies against canine thyroglobulin in dogs.

Design—Prospective study.

Animals—20 healthy research Beagles and 16 healthy pet dogs.

Procedure—For the research Beagles, 5 dogs were vaccinated with a multivalent vaccine and a rabies vaccine, 5 dogs received only the multivalent vaccine, 5 dogs received only the rabies vaccine, and 5 dogs were unvaccinated controls. The multivalent vaccine was administered at 8, 10, 12, 16, 20, 26, and 52 weeks of age and every 6 months thereafter. The rabies vaccine was administered at 16 and 52 weeks of age and then once per year. Blood was collected from all dogs at 8, 16, and 26 weeks of age and then 4 times yearly. Assays for antibodies directed against bovine and canine thyroglobulin were performed prior to and 2 weeks after each yearly vaccination. For the pet dogs, blood was collected prior to and 2 weeks after 1 vaccination.

Results—In the research Beagles, there was a significant increase in anti-bovine thyroglobulin antibodies in all vaccinated dogs, compared with control dogs. There was a significant increase in anti-canine thyroglobulin antibodies in the 2 groups of dogs that received the rabies vaccine but not in the group that received the multivalent vaccine alone. In the pet dogs, there was a significant increase in anti-canine thyroglobulin antibodies after vaccination but no significant change in anti-bovine thyroglobulin antibodies.

Conclusions and Clinical Relevance—Recent vaccination may result in increased anti-canine thyroglobulin antibodies. Whether these antibodies have a deleterious effect on canine thyroid function is unknown. (J Am Vet Med Assoc 2002;221:515–521)

All Time Past Year Past 30 Days
Abstract Views 225 0 0
Full Text Views 1167 829 38
PDF Downloads 356 140 20
Advertisement