Efficacy of florfenicol for treatment of naturally occurring infectious bovine keratoconjunctivitis

John A. Angelos Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.

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Erica L. Dueger Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.

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Lisle W. George Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.

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Tracey K. Carrier Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.
Present address: Third Avenue Animal Medical Center, 1280 3rd Ave, Chula Vista, CA 91911.

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Judy E. Mihalyi Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616.

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Sallie B. Cosgrove Schering-Plough Animal Health Corp, 1095 Morris Ave, Union, NJ 07083.

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John C. Johnson Schering-Plough Animal Health Corp, PO Box 3113, Omaha, NE 68103.

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Abstract

Objective—To determine the efficacy of florfenicol for treatment of calves with naturally occurring infectious bovine keratoconjunctivitis (IBK).

Design—Randomized controlled field trial.

Animals—63 beef calves and 80 dairy calves between 4 and 12 months of age.

Procedure—Calves were randomly assigned to 1 of 3 treatment groups. Calves in the SC treatment group received a single dose of florfenicol (40 mg/kg [18.2 mg/lb] of body weight), SC, on day 0. Calves in the IM treatment group received florfenicol (20 mg/kg [9.1 mg/lb]), IM, on days 0 and 2. Calves in the control group received injections of saline solution (0.9% NaCl), IM, on days 0 and 2. Calves were reevaluated every other day for 20 days after treatment.

Results—Corneal ulcers healed by day 20 in 48 of 49 (98%) calves treated with florfenicol IM, 39 of 42 (93%) calves treated with florfenicol SC, and 33 of 52 (63%) control calves.

Conclusions and Clinical Relevance—Florfenicol administered SC (1 dose) or IM (2 doses 48 hours apart) was effective for treatment of calves with naturally occurring IBK. ( J Am Vet Med Assoc 2000;216: 62–64)

Abstract

Objective—To determine the efficacy of florfenicol for treatment of calves with naturally occurring infectious bovine keratoconjunctivitis (IBK).

Design—Randomized controlled field trial.

Animals—63 beef calves and 80 dairy calves between 4 and 12 months of age.

Procedure—Calves were randomly assigned to 1 of 3 treatment groups. Calves in the SC treatment group received a single dose of florfenicol (40 mg/kg [18.2 mg/lb] of body weight), SC, on day 0. Calves in the IM treatment group received florfenicol (20 mg/kg [9.1 mg/lb]), IM, on days 0 and 2. Calves in the control group received injections of saline solution (0.9% NaCl), IM, on days 0 and 2. Calves were reevaluated every other day for 20 days after treatment.

Results—Corneal ulcers healed by day 20 in 48 of 49 (98%) calves treated with florfenicol IM, 39 of 42 (93%) calves treated with florfenicol SC, and 33 of 52 (63%) control calves.

Conclusions and Clinical Relevance—Florfenicol administered SC (1 dose) or IM (2 doses 48 hours apart) was effective for treatment of calves with naturally occurring IBK. ( J Am Vet Med Assoc 2000;216: 62–64)

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