Antibiotic residues in milk samples obtained from cows after treatment for papillomatous digital dermatitis

Jenks S. Britt From the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1102 (Britt); Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708 (Carson, von Bredow, Condon).

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Mary C. Carson From the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1102 (Britt); Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708 (Carson, von Bredow, Condon).

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Jurgen D. von Bredow From the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1102 (Britt); Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708 (Carson, von Bredow, Condon).

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Robert J. Condon From the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1102 (Britt); Office of Research, Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD 20708 (Carson, von Bredow, Condon).

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Objective

To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline.

Design

Randomized controlled clinical trial.

Animals

28 lactating Holstein cows with PDD.

Procedure

Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test.

Results

None of the cows in either treatment group had violative residues of oxytetracycline in milk samples.

Conclusions and Clinical Relevance

Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk. (J Am Vet Med Assoc 1999;215:833–836)

Objective

To determine whether there would be detectable antibiotic residues in milk obtained from dairy cattle with papillomatous digital dermatitis (PDD) after topical treatment with oxytetracycline.

Design

Randomized controlled clinical trial.

Animals

28 lactating Holstein cows with PDD.

Procedure

Cows were assigned to 2 treatment groups. Treatment 1 (n = 16) consisted of spraying of PDD lesions with 15 ml of a solution containing 100 mg of oxytetracycline/ml; lesions were sprayed twice daily for 7 days, using a garden sprayer. Treatment 2 (n = 12) consisted of a one-time application of a bandage that consisted of cotton soaked with 20 ml of a solution containing 100 mg of oxytetracycline/ml. Milk samples were obtained before and after treatment and assayed for tetracycline content by use of high-performance liquid chromatography and a commercially available tetracycline screening test.

Results

None of the cows in either treatment group had violative residues of oxytetracycline in milk samples.

Conclusions and Clinical Relevance

Producers treating lactating cows that have PDD, via topical application of oxytetracycline solution at the concentrations reported in this study, have a low risk of causing violative antibiotic residues in milk. (J Am Vet Med Assoc 1999;215:833–836)

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