Clinicopathologic features of dogs with hepatic microvascular dysplasia with and without portosystemic shunts: 42 cases (1991–1996)

Larie Allen From the Department of Surgery and Pathology, Bobst Hospital, Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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Daniel Stobie From the Department of Surgery and Pathology, Bobst Hospital, Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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G. Neal Mauldin From the Department of Surgery and Pathology, Bobst Hospital, Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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Keith E. Baer From the Department of Surgery and Pathology, Bobst Hospital, Animal Medical Center, 510 E 62nd St, New York, NY 10021.

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Objective

To identify and compare clinicopathologic features between dogs with hepatic microvascular dysplasia (HMD) and confirmed portosystemic shunts (PSS) and dogs with HMD alone and to determine whether any discriminating variables can be identified to differentiate the conditions.

Design

Retrospective study.

Animals

42 dogs with HMD.

Procedure

Medical records of dogs with HMD examined between January 1991 and October 1996 at 3 veterinary hospitals were reviewed.

Results

Compared with dogs with PSS and HMD, dogs with HMD alone were older and had higher values for mean corpuscular volume (MCV) and serum total protein, albumin, creatinine, cholesterol, BUN, and blood glucose concentrations. Compared with dogs with HMD alone, dogs with PSS and HMD had higher values for pre- and postprandial serum bile acid concentrations, WBC, and serum alkaline phosphatase and aspartate aminotransferase activities. The most discriminating variables for the 2 conditions were serum postprandial bile acid concentrations, MCV, and serum albumin and cholesterol concentrations.

Clinical Implications

The discriminant variables of postprandial serum bile acid concentrations, MCV, and serum albumin and cholesterol concentrations may be useful in distinguishing between dogs with HMD alone and dogs with PSS and HMD. (J Am Vet Med Assoc 1999;214:218–220)

Objective

To identify and compare clinicopathologic features between dogs with hepatic microvascular dysplasia (HMD) and confirmed portosystemic shunts (PSS) and dogs with HMD alone and to determine whether any discriminating variables can be identified to differentiate the conditions.

Design

Retrospective study.

Animals

42 dogs with HMD.

Procedure

Medical records of dogs with HMD examined between January 1991 and October 1996 at 3 veterinary hospitals were reviewed.

Results

Compared with dogs with PSS and HMD, dogs with HMD alone were older and had higher values for mean corpuscular volume (MCV) and serum total protein, albumin, creatinine, cholesterol, BUN, and blood glucose concentrations. Compared with dogs with HMD alone, dogs with PSS and HMD had higher values for pre- and postprandial serum bile acid concentrations, WBC, and serum alkaline phosphatase and aspartate aminotransferase activities. The most discriminating variables for the 2 conditions were serum postprandial bile acid concentrations, MCV, and serum albumin and cholesterol concentrations.

Clinical Implications

The discriminant variables of postprandial serum bile acid concentrations, MCV, and serum albumin and cholesterol concentrations may be useful in distinguishing between dogs with HMD alone and dogs with PSS and HMD. (J Am Vet Med Assoc 1999;214:218–220)

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