Chronic granulocytic leukemia in a dog

Deborah M. Fine From the Departments of Small Animal Clinical Sciences (Fine) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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Harold W. Tvedten From the Departments of Small Animal Clinical Sciences (Fine) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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  • Chronic granulocytic leukemia is an uncommon myeloproliferative disorder that results in substantial proliferation of mature granulocytes.

  • Because the severe leukocytosis and left shift observed with chronic granulocytic leukemia may strongly resemble a leukemoid reaction, other causes of severe leukocytosis must be ruled out.

  • Myeloid cellular infiltrations may cause hepatomegaly, splenomegaly, or nonregenerative anemia and thrombocytopenia.

  • Commonly, results of serum biochemical analyses are only minimally altered or within reference ranges and clinical signs are nonspecific.

  • Chronic granulocytic leukemia is an uncommon myeloproliferative disorder that results in substantial proliferation of mature granulocytes.

  • Because the severe leukocytosis and left shift observed with chronic granulocytic leukemia may strongly resemble a leukemoid reaction, other causes of severe leukocytosis must be ruled out.

  • Myeloid cellular infiltrations may cause hepatomegaly, splenomegaly, or nonregenerative anemia and thrombocytopenia.

  • Commonly, results of serum biochemical analyses are only minimally altered or within reference ranges and clinical signs are nonspecific.

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