Evaluation of risk factors for fatal acute pancreatitis in dogs

Rebecka S. Hess From the Departments of Clinical Studies (Hess, Shofer, Washabau) and Pathobiology (Van Winkle), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010; and the Section of Biometrics and Preventive Medicine, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616 (Kass).

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Philip H. Kass From the Departments of Clinical Studies (Hess, Shofer, Washabau) and Pathobiology (Van Winkle), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010; and the Section of Biometrics and Preventive Medicine, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616 (Kass).

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Frances S. Shofer From the Departments of Clinical Studies (Hess, Shofer, Washabau) and Pathobiology (Van Winkle), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010; and the Section of Biometrics and Preventive Medicine, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616 (Kass).

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Thomas J. Van Winkle From the Departments of Clinical Studies (Hess, Shofer, Washabau) and Pathobiology (Van Winkle), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010; and the Section of Biometrics and Preventive Medicine, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616 (Kass).

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Robert J. Washabau From the Departments of Clinical Studies (Hess, Shofer, Washabau) and Pathobiology (Van Winkle), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010; and the Section of Biometrics and Preventive Medicine, Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616 (Kass).

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Objective

To identify risk factors associated with fatal acute pancreatitis in dogs.

Design

Case-control study.

Animals

70 case dogs with clinical evidence and histopathologic confirmation of fatal acute pancreatitis and 104 control dogs that had trauma, underwent necropsy, and did not have histologic evidence of acute pancreatitis.

Procedure

Information on signalment, weight, body condition, medical history, concurrent disease, and results of histopathologic examination was obtained by reviewing medical records. Logistic regression analysis included calculation of univariate and multivariate (adjusted) odds ratios and 95% confidence intervals.

Results and Clinical Implications

Dogs with fatal acute pancreatitis were largely middle- to older-aged dogs. Risk of developing fatal acute pancreatitis was increased by overweight body condition, diabetes mellitus, hyperadrenocorticism, hypothyroidism, prior gastrointestinal tract disease, and epilepsy. Additionally, Yorkshire Terriers were at increased risk, and Labrador Retrievers and Miniature Poodles were at decreased risk, of developing fatal acute pancreatitis. Males and neutered females appeared to have an increased risk of developing fatal acute pancreatitis, compared with sexually intact females. Thrombus formation was more likely in dogs that developed fatal acute pancreatitis than in control dogs. (J Am Vet Med Assoc 1999;214:46–51)

Objective

To identify risk factors associated with fatal acute pancreatitis in dogs.

Design

Case-control study.

Animals

70 case dogs with clinical evidence and histopathologic confirmation of fatal acute pancreatitis and 104 control dogs that had trauma, underwent necropsy, and did not have histologic evidence of acute pancreatitis.

Procedure

Information on signalment, weight, body condition, medical history, concurrent disease, and results of histopathologic examination was obtained by reviewing medical records. Logistic regression analysis included calculation of univariate and multivariate (adjusted) odds ratios and 95% confidence intervals.

Results and Clinical Implications

Dogs with fatal acute pancreatitis were largely middle- to older-aged dogs. Risk of developing fatal acute pancreatitis was increased by overweight body condition, diabetes mellitus, hyperadrenocorticism, hypothyroidism, prior gastrointestinal tract disease, and epilepsy. Additionally, Yorkshire Terriers were at increased risk, and Labrador Retrievers and Miniature Poodles were at decreased risk, of developing fatal acute pancreatitis. Males and neutered females appeared to have an increased risk of developing fatal acute pancreatitis, compared with sexually intact females. Thrombus formation was more likely in dogs that developed fatal acute pancreatitis than in control dogs. (J Am Vet Med Assoc 1999;214:46–51)

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