Occult osseous metastasis of a colonic adenocarcinoma visualized with technetium Tc 99m hydroxymethylene diphosphate scintigraphy in a horse
Leslie M. East
 DVM
Leslie M. East
From the Departments of Veterinary Clinical Sciences (East, Dickinson), Radiologic Health Sciences (Steyn), and Pathology (Frank), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W Drake, Fort Collins, CO 80523.
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Phillip F. Steyn
 BVSc, MS
Phillip F. Steyn
From the Departments of Veterinary Clinical Sciences (East, Dickinson), Radiologic Health Sciences (Steyn), and Pathology (Frank), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W Drake, Fort Collins, CO 80523.
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Charles E. Dickinson
 DVM, MS
Charles E. Dickinson
From the Departments of Veterinary Clinical Sciences (East, Dickinson), Radiologic Health Sciences (Steyn), and Pathology (Frank), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W Drake, Fort Collins, CO 80523.
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Anthony A. Frank
 DVM, PhD
Anthony A. Frank
From the Departments of Veterinary Clinical Sciences (East, Dickinson), Radiologic Health Sciences (Steyn), and Pathology (Frank), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 W Drake, Fort Collins, CO 80523.
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Colonic adenocarcinoma is a rare tumor of glandular crypt epithelium in middle-aged and older horses; the tumor may metastasize to the mesenteric lymph nodes, liver, and lungs, but it has not been reported to metastasize to bone and muscle.
Clinical signs of abdominal neoplasia may be vague and nonspecific; extensive diagnostic testing of these animals often is required.
Radionucleotide imaging, using technetium Tc 99m hydroxymethylene diphosphate in conjunction with technetium Tc 99m hexamethylpropylenamine oxime, can be a sensitive noninvasive tool to identify the nature of a disseminated disease when radiography is not sensitive enough to detect early osteoblastic changes that precede morphologic changes.
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