Detection and effects of Helicobacters in healthy dogs and dogs with signs of gastritis

Irmeli Happonen From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Jere Linden From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Seppo Saari From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Mari Karjalainen From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Marja-Liisa Hänninen From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Katri Jalava From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Elias Westermarck From the Departments of Clinical Veterinary Sciences (Happonen, Karjalainen, Westermarck), Basic Veterinary Sciences (Linden), and Food and Environmental Hygiene (Hänninen, Jalava), Faculty of Veterinary Medicine, University of Helsinki, PO Box 57 (Hämeentie 57), FIN-00014 Helsinki University, Helsinki, Finland, and Department of Pathology, National Veterinary and Food Research Institute, PO Box 368, FIN-00231 Helsinki, Finland (Saari).

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Objectives

To determine prevalence, colonization density, and distribution of helicobacters and gastric histologic findings in healthy dogs and dogs with signs of gastritis; to evaluate association of colonization density and gastric inflammation; and to compare the number of Helicobacter spp with degree of inflammation.

Design

Cross-sectional prevalence survey.

Animals

25 healthy dogs and 21 dogs with signs of gastritis.

Procedure

During endoscopy, gastric mucosal biopsy specimens were obtained from healthy and affected client-owned dogs. Histologic and cytologic evaluation and results of a urease test were used for detecting helicobacters, which were identified definitively by use of transmission electron microscopy and bacterial culture.

Results

Helicobacters were detected in all 25 healthy and 20 of 21 affected dogs. Cytologic examination was a more sensitive method than histologic examination or the urease test. Helicobacters were found least frequently and in fewest number in the antrum in both groups of dogs. Gastric inflammation was evident in both groups of dogs and did not differ significantly between groups. A significant association was not detected between colonization density or the number of Helicobacter spp and degree of gastric inflammation. In both groups, H bizzozeronii, H felis, and H salomonis were cultured.

Clinical Implications

Histologically verified chronic gastritis is common in dogs with signs of gastritis as well as in healthy dogs. Colonization density of helicobacters was not associated with degree of gastric inflammation in the dogs of our study. It remains to be determined whether certain strains of Helicobacter spp can induce gastritis in dogs. (J Am Vet Med Assoc 1998;213:1767–1774)

Objectives

To determine prevalence, colonization density, and distribution of helicobacters and gastric histologic findings in healthy dogs and dogs with signs of gastritis; to evaluate association of colonization density and gastric inflammation; and to compare the number of Helicobacter spp with degree of inflammation.

Design

Cross-sectional prevalence survey.

Animals

25 healthy dogs and 21 dogs with signs of gastritis.

Procedure

During endoscopy, gastric mucosal biopsy specimens were obtained from healthy and affected client-owned dogs. Histologic and cytologic evaluation and results of a urease test were used for detecting helicobacters, which were identified definitively by use of transmission electron microscopy and bacterial culture.

Results

Helicobacters were detected in all 25 healthy and 20 of 21 affected dogs. Cytologic examination was a more sensitive method than histologic examination or the urease test. Helicobacters were found least frequently and in fewest number in the antrum in both groups of dogs. Gastric inflammation was evident in both groups of dogs and did not differ significantly between groups. A significant association was not detected between colonization density or the number of Helicobacter spp and degree of gastric inflammation. In both groups, H bizzozeronii, H felis, and H salomonis were cultured.

Clinical Implications

Histologically verified chronic gastritis is common in dogs with signs of gastritis as well as in healthy dogs. Colonization density of helicobacters was not associated with degree of gastric inflammation in the dogs of our study. It remains to be determined whether certain strains of Helicobacter spp can induce gastritis in dogs. (J Am Vet Med Assoc 1998;213:1767–1774)

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