Efficacy of clomipramine in the treatment of canine compulsive disorder

Caroline J. Hewson From the Department of Animal and Poultry Science (Hewson, Ball), Ontario Agricultural College; and Departments of Population Medicine (Hewson, Luescher), Clinical Studies (Parent) and Biomedical Sciences (Conlon), Ontario Veterinary College, University of Guelph, Guelph, Ontario NIG 2W1, Canada.

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 MVB, PhD
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U. Andrew Luescher From the Department of Animal and Poultry Science (Hewson, Ball), Ontario Agricultural College; and Departments of Population Medicine (Hewson, Luescher), Clinical Studies (Parent) and Biomedical Sciences (Conlon), Ontario Veterinary College, University of Guelph, Guelph, Ontario NIG 2W1, Canada.

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Joane M. Parent From the Department of Animal and Poultry Science (Hewson, Ball), Ontario Agricultural College; and Departments of Population Medicine (Hewson, Luescher), Clinical Studies (Parent) and Biomedical Sciences (Conlon), Ontario Veterinary College, University of Guelph, Guelph, Ontario NIG 2W1, Canada.

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Peter D. Conlon From the Department of Animal and Poultry Science (Hewson, Ball), Ontario Agricultural College; and Departments of Population Medicine (Hewson, Luescher), Clinical Studies (Parent) and Biomedical Sciences (Conlon), Ontario Veterinary College, University of Guelph, Guelph, Ontario NIG 2W1, Canada.

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Ronald O. Ball From the Department of Animal and Poultry Science (Hewson, Ball), Ontario Agricultural College; and Departments of Population Medicine (Hewson, Luescher), Clinical Studies (Parent) and Biomedical Sciences (Conlon), Ontario Veterinary College, University of Guelph, Guelph, Ontario NIG 2W1, Canada.

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 BSc(Ag), PhD

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Objective

To assess the efficacy of clomipramine for treatment of canine compulsive disorder (CCD).

Design

Randomized, placebo-controlled, double-blind, balanced AB-BA crossover clinical study

Animals

51 dogs with CCD.

Procedures

Dogs were given clomipramine (3 mg/kg [1.3 mg/lb] of body weight, PO, q 12 h) for 4 weeks and placebo for 4 weeks. At the end of each treatment each owner rated the severity of their dog's behavior, using 2 validated rating scales. Statistical analysis was made by ordinal regression. Compliance, adverse effects, and the effectiveness of masking were also assessed. Each dog's behavior was reevaluated 1 to 2 years after completing the study.

Results

Behaviors included spinning (n = 17) and self-mutilation by licking (acral lick dermatitis, 12). Both rating scales demonstrated a treatment effect. Compliance was satisfactory, and masking was effective. Sedation and reduced appetite were reported more commonly when dogs were given clomipramine than when they were given placebo. Forty-five dogs available for follow-up evaluation still had their behaviors; 6 dogs were lost to follow-up evaluation.

Clinical Implications

Results suggest that clomipramine was effective in dogs with CCD and was not associated with serious adverse effects. However, treatment for 4 weeks was not curative. Behavior modification is likely to be necessary to manage CCD. (J Am Vet Med Assoc 1998;213:1760–1766)

Objective

To assess the efficacy of clomipramine for treatment of canine compulsive disorder (CCD).

Design

Randomized, placebo-controlled, double-blind, balanced AB-BA crossover clinical study

Animals

51 dogs with CCD.

Procedures

Dogs were given clomipramine (3 mg/kg [1.3 mg/lb] of body weight, PO, q 12 h) for 4 weeks and placebo for 4 weeks. At the end of each treatment each owner rated the severity of their dog's behavior, using 2 validated rating scales. Statistical analysis was made by ordinal regression. Compliance, adverse effects, and the effectiveness of masking were also assessed. Each dog's behavior was reevaluated 1 to 2 years after completing the study.

Results

Behaviors included spinning (n = 17) and self-mutilation by licking (acral lick dermatitis, 12). Both rating scales demonstrated a treatment effect. Compliance was satisfactory, and masking was effective. Sedation and reduced appetite were reported more commonly when dogs were given clomipramine than when they were given placebo. Forty-five dogs available for follow-up evaluation still had their behaviors; 6 dogs were lost to follow-up evaluation.

Clinical Implications

Results suggest that clomipramine was effective in dogs with CCD and was not associated with serious adverse effects. However, treatment for 4 weeks was not curative. Behavior modification is likely to be necessary to manage CCD. (J Am Vet Med Assoc 1998;213:1760–1766)

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