Comparison of hypertonic saline-dextran solution and lactated Ringer's solution for resuscitating severely dehydrated calves with diarrhea

Pamela G. Walker From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine (Walker, Constable, Morin, Foreman, Thurmon), and the Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences (Drackley), University of Illinois, Urbana, IL 61802.

Search for other papers by Pamela G. Walker in
Current site
Google Scholar
PubMed
Close
 DVM
,
Peter D. Constable From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine (Walker, Constable, Morin, Foreman, Thurmon), and the Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences (Drackley), University of Illinois, Urbana, IL 61802.

Search for other papers by Peter D. Constable in
Current site
Google Scholar
PubMed
Close
 BVSc, PhD
,
Dawn E. Morin From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine (Walker, Constable, Morin, Foreman, Thurmon), and the Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences (Drackley), University of Illinois, Urbana, IL 61802.

Search for other papers by Dawn E. Morin in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
Jonathan H. Foreman From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine (Walker, Constable, Morin, Foreman, Thurmon), and the Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences (Drackley), University of Illinois, Urbana, IL 61802.

Search for other papers by Jonathan H. Foreman in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
James K. Drackley From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine (Walker, Constable, Morin, Foreman, Thurmon), and the Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences (Drackley), University of Illinois, Urbana, IL 61802.

Search for other papers by James K. Drackley in
Current site
Google Scholar
PubMed
Close
 PhD
, and
John C. Thurmon From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine (Walker, Constable, Morin, Foreman, Thurmon), and the Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences (Drackley), University of Illinois, Urbana, IL 61802.

Search for other papers by John C. Thurmon in
Current site
Google Scholar
PubMed
Close
 DVM, MS

Click on author name to view affiliation information

Objective

To determine effectiveness of rapid IV administration of hypertonic saline-dextran (HSD) solution combined with oral administration of isotonic electrolyte solution for resuscitating severely dehydrated calves and to compare the resuscitative response with that of a conventional treatment of lactated Ringer's solution (LRS) IV and orally administered isotonic electrolyte solution.

Design

Prospective study.

Animals

15 male dairy calves 3 to 10 days old.

Procedure

Baseline data were obtained. Osmotic diarrhea and severe dehydration were induced for 48 hours. Calves were then allocated to 3 treatment groups. The control group (group C) did not receive fluids, a second group (group H) received hypertonic saline (7.2% NaCI) solution with 6% dextran 70 and isotonic electrolyte solution, and a third group (group L) received LRS and isotonic electrolyte solution. Physical examinations were performed every 8 hours.

Results

Calves developed diarrhea, lethargy, severe dehydration (mean, 14% of body weight), azotemia, hyperkalemia, and mild acidemia. Group-C calves remained lethargic and severely dehydrated during the 24-hour treatment phase. Calves treated with HSD and LRS were effectively resuscitated; however, response for most variables was more rapid and sustained for the HSD-treated group. Cardiac output was greater in LRS- than HSD-treated calves 1, 2, and 8 hours after initiation of treatment because of continued IV administration of fluids.

Clinical Implications

A combination of HSD and isotonic electrolyte solution was a rapid and effective method for resuscitation of severely dehydrated calves. It was similar in effectiveness to conventional treatment in which LRS and isotonic electrolyte solution were used for resuscitating calves with severe dehydration.(J Am Vet Med Accoc 1998;213:113-121)

Objective

To determine effectiveness of rapid IV administration of hypertonic saline-dextran (HSD) solution combined with oral administration of isotonic electrolyte solution for resuscitating severely dehydrated calves and to compare the resuscitative response with that of a conventional treatment of lactated Ringer's solution (LRS) IV and orally administered isotonic electrolyte solution.

Design

Prospective study.

Animals

15 male dairy calves 3 to 10 days old.

Procedure

Baseline data were obtained. Osmotic diarrhea and severe dehydration were induced for 48 hours. Calves were then allocated to 3 treatment groups. The control group (group C) did not receive fluids, a second group (group H) received hypertonic saline (7.2% NaCI) solution with 6% dextran 70 and isotonic electrolyte solution, and a third group (group L) received LRS and isotonic electrolyte solution. Physical examinations were performed every 8 hours.

Results

Calves developed diarrhea, lethargy, severe dehydration (mean, 14% of body weight), azotemia, hyperkalemia, and mild acidemia. Group-C calves remained lethargic and severely dehydrated during the 24-hour treatment phase. Calves treated with HSD and LRS were effectively resuscitated; however, response for most variables was more rapid and sustained for the HSD-treated group. Cardiac output was greater in LRS- than HSD-treated calves 1, 2, and 8 hours after initiation of treatment because of continued IV administration of fluids.

Clinical Implications

A combination of HSD and isotonic electrolyte solution was a rapid and effective method for resuscitation of severely dehydrated calves. It was similar in effectiveness to conventional treatment in which LRS and isotonic electrolyte solution were used for resuscitating calves with severe dehydration.(J Am Vet Med Accoc 1998;213:113-121)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 588 588 166
PDF Downloads 53 53 3
Advertisement