Effects of an allicin-based product on cryptosporidiosis in neonatal calves

Erik J. Olson From the Departments of Biology and Microbiology (Olson, Hildreth) and Veterinary Science (Epperson, Zeman, Hildreth), College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD 57007, and Immunity and Disease Prevention Laboratory, Livestock and Poultry Science Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 (Fayer).

Search for other papers by Erik J. Olson in
Current site
Google Scholar
PubMed
Close
 BA
,
William B. Epperson From the Departments of Biology and Microbiology (Olson, Hildreth) and Veterinary Science (Epperson, Zeman, Hildreth), College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD 57007, and Immunity and Disease Prevention Laboratory, Livestock and Poultry Science Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 (Fayer).

Search for other papers by William B. Epperson in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
David H. Zeman From the Departments of Biology and Microbiology (Olson, Hildreth) and Veterinary Science (Epperson, Zeman, Hildreth), College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD 57007, and Immunity and Disease Prevention Laboratory, Livestock and Poultry Science Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 (Fayer).

Search for other papers by David H. Zeman in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Ronald Fayer From the Departments of Biology and Microbiology (Olson, Hildreth) and Veterinary Science (Epperson, Zeman, Hildreth), College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD 57007, and Immunity and Disease Prevention Laboratory, Livestock and Poultry Science Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 (Fayer).

Search for other papers by Ronald Fayer in
Current site
Google Scholar
PubMed
Close
 PhD
, and
Michael B. Hildreth From the Departments of Biology and Microbiology (Olson, Hildreth) and Veterinary Science (Epperson, Zeman, Hildreth), College of Agriculture and Biological Sciences, South Dakota State University, Brookings, SD 57007, and Immunity and Disease Prevention Laboratory, Livestock and Poultry Science Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 (Fayer).

Search for other papers by Michael B. Hildreth in
Current site
Google Scholar
PubMed
Close
 PhD

Click on author name to view affiliation information

Objective

To evaluate effectiveness of an allicin-based product in neonatal calves inoculated with Cryptosporidium parvum.

Design

Randomized controlled study.

Animals

43 neonatal calves.

Procedure

Calves were inoculated with 1.5 × l06 or 7.5 × 105 C parvum oocysts within 2 days after birth. Calves were given an allicin-based product once after inoculation or daily for 7 days after inoculation or were not treated. Calves that developed diarrhea were treated by administration of the product. Fecal consistency scores and weight gains were statistically evaluated.

Results

Mean daily weight gain and severity of diarrhea in calves 4 to 21 days old were unaffected by prophylactic use of the product. However, intensive prophylactic administration may have delayed onset of C parvum-induced diarrhea in calves inoculated with the lower dose of oocysts.

Clinical Implications

Administration of an allicin-based product did not alter duration of C parvum-induced diarrhea or enhance weight gain in neonatal calves. However, intensive prophylactic administration of an allicin-based product may delay onset of diarrhea in calves exposed to C parvum oocysts. (J Am Vet Med Assoc 1998;212:987–990)

Objective

To evaluate effectiveness of an allicin-based product in neonatal calves inoculated with Cryptosporidium parvum.

Design

Randomized controlled study.

Animals

43 neonatal calves.

Procedure

Calves were inoculated with 1.5 × l06 or 7.5 × 105 C parvum oocysts within 2 days after birth. Calves were given an allicin-based product once after inoculation or daily for 7 days after inoculation or were not treated. Calves that developed diarrhea were treated by administration of the product. Fecal consistency scores and weight gains were statistically evaluated.

Results

Mean daily weight gain and severity of diarrhea in calves 4 to 21 days old were unaffected by prophylactic use of the product. However, intensive prophylactic administration may have delayed onset of C parvum-induced diarrhea in calves inoculated with the lower dose of oocysts.

Clinical Implications

Administration of an allicin-based product did not alter duration of C parvum-induced diarrhea or enhance weight gain in neonatal calves. However, intensive prophylactic administration of an allicin-based product may delay onset of diarrhea in calves exposed to C parvum oocysts. (J Am Vet Med Assoc 1998;212:987–990)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 294 294 72
PDF Downloads 42 42 8
Advertisement