Effect of dietary insoluble fiber on control of glycemia in dogs with naturally acquired diabetes mellitus

Richard W. Nelson From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Cindy A. Duesberg From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Sara L. Ford From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Edward C. Feldman From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Deborah J. Davenport From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Christine Kiernan From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Larry Neal From the Department of Medicine and Epidemiology (Nelson, Feldman, Neal) and the Veterinary Medical Teaching Hospital (Duesberg, Ford, Kiernan), School of Veterinary Medicine, University of California, Davis, CA 95616-8734, and Mark Morris Associates, PO Box 1658, Topeka, KS 66601 (Davenport).

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Objective

To evaluate the effect of a high insolublefiber (HF) diet containing 12% cellulose in dry matter and a low insoluble-fiber (LF) diet on control of glycemia in dogs with naturally acquired insulin-dependent diabetes mellitus.

Design

Prospective randomized crossover controlled trial.

Animals

11 dogs with naturally acquired diabetes mellitus.

Procedure

Dogs were fed HF and LF diets for 8 months each in 1 of 2 randomly assigned diet sequences. Caloric intake and insulin treatment were adjusted as needed to maintain stable body weight and control of glycemia, respectively. After a 2-month adaptation period, control of glycemia was evaluated every 6 weeks for 6 months. Variables assessed included serum glucose concentration measured during the preprandial state, blood glycosylated hemoglobin concentration, serum glucose concentration measured every 2 hours for 24 hours beginning at the time of the morning insulin injection, 24-hour mean serum glucose concentration, mean serum glucose concentration fluctuation from the 24-hour mean serum glucose concentration, and 24-hour urinary excretion of glucose.

Results

Significant differences in mean daily caloric intake, body weight, or daily insulin dosage among dogs fed HF and LF diets were not found. Mean preprandial serum glucose concentration, most postprandial serum glucose concentrations, 24-hour mean serum glucose concentration, and 24-hour urinary excretion of glucose were significantly lower in dogs fed the HF diet, compared with the LF diet.

Clinical Implications

Results of this study support feeding of commercially available insoluble fiber diets to dogs with naturally acquired diabetes mellitus. (J Am Vet Med Assoc 1998; 212:380-386)

Objective

To evaluate the effect of a high insolublefiber (HF) diet containing 12% cellulose in dry matter and a low insoluble-fiber (LF) diet on control of glycemia in dogs with naturally acquired insulin-dependent diabetes mellitus.

Design

Prospective randomized crossover controlled trial.

Animals

11 dogs with naturally acquired diabetes mellitus.

Procedure

Dogs were fed HF and LF diets for 8 months each in 1 of 2 randomly assigned diet sequences. Caloric intake and insulin treatment were adjusted as needed to maintain stable body weight and control of glycemia, respectively. After a 2-month adaptation period, control of glycemia was evaluated every 6 weeks for 6 months. Variables assessed included serum glucose concentration measured during the preprandial state, blood glycosylated hemoglobin concentration, serum glucose concentration measured every 2 hours for 24 hours beginning at the time of the morning insulin injection, 24-hour mean serum glucose concentration, mean serum glucose concentration fluctuation from the 24-hour mean serum glucose concentration, and 24-hour urinary excretion of glucose.

Results

Significant differences in mean daily caloric intake, body weight, or daily insulin dosage among dogs fed HF and LF diets were not found. Mean preprandial serum glucose concentration, most postprandial serum glucose concentrations, 24-hour mean serum glucose concentration, and 24-hour urinary excretion of glucose were significantly lower in dogs fed the HF diet, compared with the LF diet.

Clinical Implications

Results of this study support feeding of commercially available insoluble fiber diets to dogs with naturally acquired diabetes mellitus. (J Am Vet Med Assoc 1998; 212:380-386)

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