Evaluation of serum ɣ-glutamyltransferase activity as a predictor of passive transfer status in crias

Nancy A. Johnston From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7010 (Johnston, Parish); Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211 (Tyler); and 20510 Swalley Rd, Bend, OR 97701 (Tillman).

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Steven M. Parish From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7010 (Johnston, Parish); Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211 (Tyler); and 20510 Swalley Rd, Bend, OR 97701 (Tillman).

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Jeff W. Tyler From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7010 (Johnston, Parish); Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211 (Tyler); and 20510 Swalley Rd, Bend, OR 97701 (Tillman).

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Cheryl Blake Tillman From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7010 (Johnston, Parish); Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211 (Tyler); and 20510 Swalley Rd, Bend, OR 97701 (Tillman).

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Objective

To determine the relationship between serum ɣ-glutamyltransferase (GGT) activity and serum IgG concentration in neonatal crias.

Design

Prospective observational study.

Animals

21 llama and 4 alpaca crias from 0 to 5 days old.

Procedure

Serum GGT activity was measured, using a commercially available kit. Serum IgG concentration was determined by use of radial immunodiffusion. With a serum IgG concentration of 1,000 mg/dl (considered adequate passive transfer), specificity and sensitivity of serum GGT activity in the detection of failure of passive transfer were determined. Regression models were developed to determine the relationship between serum GGT activity and serum IgG concentration.

Results

Sensitivity ranged from 0.56 to 0.89, and specificity ranged from 0.88 to 0.31, depending on the value of serum GGT activity chosen as a threshold. Proportion of crias correctly classified ranged from 0.76 to 0.52. Regression models failed to demonstrate a significant relationship between serum GGT activity and serum IgG concentration.

Clinical Implications

Passive transfer status in crias cannot be accurately predicted on the basis of serum GGT activity. (J Am Vet Med Assoc 1997;211:1165–1166)

Objective

To determine the relationship between serum ɣ-glutamyltransferase (GGT) activity and serum IgG concentration in neonatal crias.

Design

Prospective observational study.

Animals

21 llama and 4 alpaca crias from 0 to 5 days old.

Procedure

Serum GGT activity was measured, using a commercially available kit. Serum IgG concentration was determined by use of radial immunodiffusion. With a serum IgG concentration of 1,000 mg/dl (considered adequate passive transfer), specificity and sensitivity of serum GGT activity in the detection of failure of passive transfer were determined. Regression models were developed to determine the relationship between serum GGT activity and serum IgG concentration.

Results

Sensitivity ranged from 0.56 to 0.89, and specificity ranged from 0.88 to 0.31, depending on the value of serum GGT activity chosen as a threshold. Proportion of crias correctly classified ranged from 0.76 to 0.52. Regression models failed to demonstrate a significant relationship between serum GGT activity and serum IgG concentration.

Clinical Implications

Passive transfer status in crias cannot be accurately predicted on the basis of serum GGT activity. (J Am Vet Med Assoc 1997;211:1165–1166)

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