Effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure

Laine A. Cowan From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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Ron McLaughlin From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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Philip W. Toll From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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Scott A. Brown From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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Terri L. Moore From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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Michael D. Butine From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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George Milliken From the Departments of Clinical Sciences (Cowan, McLaughlin) and Statistics (Moore, Butine, Milliken), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506; the Mark Morris Institute, Topeka, KS 66601 (Toll); and the Department of Physiology and Pharmacology, College of Veterinary Medicine University of Georgia, Athens, GA 30602 (Brown).

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Objective

To determine the effect of stanozolol on body composition, nitrogen balance, and food consumption in castrated dogs with chronic renal failure.

Design

Blinded crossover trial.

Animals

22 casated Beagles with experimentally induced chronic renal failure.

Procedure

Dogs were divided into 2 groups of 11 dogs each. During each of two 6-week treatment periods, dogs in 1 group received stanozolol, and those in the other group received a control agent. Nitrogen balance, body composition, and food consumption were determined.

Results

During administration of stanozolol, the amount of food consumed per dog, lean body mass, and nitrogen balance increased. Stanozolol did not have a significant effect on body fat, bone mineral content, or food consumption per kilogram of body weight.

Clinical Implications

For dogs with mild-to-moderate, nonuremic, experimentally induced, chronic renal failure, stanozolol had positive effects on nitrogen balance and lean body mass. (J Am Vet Med Assoc 1997;211:719–722)

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Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
Issue:
15 Sep 1997
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