Evaluation of prognostic factors for dogs with primary lung tumors: 67 cases (1985–1992)
Search for other papers by Elizabeth A. McNiel in
Current site
Google Scholar
PubMed
Search for other papers by Gregory K. Ogilvie in
Current site
Google Scholar
PubMed
Search for other papers by Barbara E. Powers in
Current site
Google Scholar
PubMed
Search for other papers by Jennifer M. Hutchison in
Current site
Google Scholar
PubMed
Search for other papers by Mowafak D. Salman in
Current site
Google Scholar
PubMed
Search for other papers by Stephen J. Withrow in
Current site
Google Scholar
PubMed
Objective
To determine associations between clinical and histologic factors in dogs with primary lung tumors and outcome and to develop a histologic grading method for primary lung tumors.
Design
Retrospective study.
Animals
67 dogs undergoing thoracotomy and lobectomy for primary lung tumors.
Procedure
Medical records and histologic sections were reviewed to evaluate factors of prognostic importance. Association of these factors with disease-free interval (DFI) and survival time was evaluated, using the Cox proportional hazards model. Median DFI and survival time were determined, using the Kaplan-Meier product-limit method.
Results
Clinical and histologic factors significantly associated with prognosis were histologic score, detection of clinical signs, and metastasis to regional lymph nodes. On the basis of histologic score, a histologic grading method was developed. Dogs with well-differentiated tumors had significantly longer survival time and DFI (median DFI, 493 days) than dogs with moderately (median DFI, 191 days) or poorly (median DFI, 0 days) differentiated tumors. Dogs with clinical signs or metastasis to regional lymph nodes had shorter survival times and DFI than dogs in which lung masses were discovered as an incidental finding.
Clinical Implications
Dogs with well-differentiated, nonmetastasized, primary lung tumors that do not have clinical signs associated with the tumor have a favorable prognosis. Dogs with more advanced disease or aggressive tumors histologically may require treatment, such as chemotherapy in combination with surgery. The grading method proposed here for primary lung tumors may be useful in other dogs with primary lung tumors. (J Am Vet Med Assoc 1997;211:1422–1427)
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 1596 | 988 | 55 |
| PDF Downloads | 994 | 710 | 51 |
