Clinical and clinicopathologic abnormalities in Greyhounds with cutaneous and renal glomerular vasculopathy: 18 cases (1992-1994)

Laine A. Cowan From the Departments of Clinical Sciences (Cowan) and Diagnostic Medicine/Pathobiology (Hertzke, Fenwick), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, and Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011(Andreasen).

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Donna M. Hertzke From the Departments of Clinical Sciences (Cowan) and Diagnostic Medicine/Pathobiology (Hertzke, Fenwick), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, and Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011(Andreasen).

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Brad W. Fenwick From the Departments of Clinical Sciences (Cowan) and Diagnostic Medicine/Pathobiology (Hertzke, Fenwick), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, and Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011(Andreasen).

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Claire B. Andreasen From the Departments of Clinical Sciences (Cowan) and Diagnostic Medicine/Pathobiology (Hertzke, Fenwick), College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, and Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011(Andreasen).

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Objective

To determine clinical signs and clinicopathologic abnormalities in Greyhounds with cutaneous and renal glomerular vasculopathy and to determine whether there were any differences between dogs with and without renal azotemia.

Design

Retrospective study.

Animals

18 Greyhounds.

Procedure

Results of CBC, serum biochemical analyses, urinalyses, coagulation tests, tests of RBC morphology, bacterial culture of blood samples, and serologic tests tor Rickettsia rickettsii, Ehrlichla canis, E platys, and Leptospira interrogans were reviewed. Glomerular filtration rates and urine protein:creatinine ratios were determined in most dogs. t-Tests and a test of equality of proportions were used to compare dogs that developed renal azotemia with dogs that did not.

Results

None of the dogs was bacteremic or had serologic evidence of infectious disease. Ten dogs had renal azotemia, 16 had anemia, 11 had hypoalbuminemia, and 18 developed thrombocytopenia. Compared with dogs without renal azotemia, dogs with renal azotemia had significantly lower mean platelet count, hematocrit, and serum albumin concentration and significantly higher mean neutrophil count and creatine kinase activity. All 10 dogs with renal azotemia died or were euthanatized; 7 of 8 dogs without azotemia survived.

Clinical Implications

Greyhounds with cutaneous and renal glomerular vasculopathy that developed renal azotemia had evidence of more severe systemic disease than did dogs that did not have azotemia and, despite supportive treatment, had a poorer prognosis.

Objective

To determine clinical signs and clinicopathologic abnormalities in Greyhounds with cutaneous and renal glomerular vasculopathy and to determine whether there were any differences between dogs with and without renal azotemia.

Design

Retrospective study.

Animals

18 Greyhounds.

Procedure

Results of CBC, serum biochemical analyses, urinalyses, coagulation tests, tests of RBC morphology, bacterial culture of blood samples, and serologic tests tor Rickettsia rickettsii, Ehrlichla canis, E platys, and Leptospira interrogans were reviewed. Glomerular filtration rates and urine protein:creatinine ratios were determined in most dogs. t-Tests and a test of equality of proportions were used to compare dogs that developed renal azotemia with dogs that did not.

Results

None of the dogs was bacteremic or had serologic evidence of infectious disease. Ten dogs had renal azotemia, 16 had anemia, 11 had hypoalbuminemia, and 18 developed thrombocytopenia. Compared with dogs without renal azotemia, dogs with renal azotemia had significantly lower mean platelet count, hematocrit, and serum albumin concentration and significantly higher mean neutrophil count and creatine kinase activity. All 10 dogs with renal azotemia died or were euthanatized; 7 of 8 dogs without azotemia survived.

Clinical Implications

Greyhounds with cutaneous and renal glomerular vasculopathy that developed renal azotemia had evidence of more severe systemic disease than did dogs that did not have azotemia and, despite supportive treatment, had a poorer prognosis.

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