Serum α1-antitrypsin concentration in dogs with panniculitis

Dez Hughes From the Center for Veterinary Critical Care (Hughes), and the Departments of Pathobiology (Goldschmidt) and Clinical Studies (Washabau), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, and the Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140 (Kueppers).

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Michael H. Goldschmidt From the Center for Veterinary Critical Care (Hughes), and the Departments of Pathobiology (Goldschmidt) and Clinical Studies (Washabau), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, and the Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140 (Kueppers).

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Robert J. Washabau From the Center for Veterinary Critical Care (Hughes), and the Departments of Pathobiology (Goldschmidt) and Clinical Studies (Washabau), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, and the Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140 (Kueppers).

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Friedrich Kueppers From the Center for Veterinary Critical Care (Hughes), and the Departments of Pathobiology (Goldschmidt) and Clinical Studies (Washabau), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, and the Department of Medicine, School of Medicine, Temple University, Philadelphia, PA 19140 (Kueppers).

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Objective

To measure serum α1-antitrypsin (α1AT) concentration in dogs with histologically confirmed panniculitis to determine whether serum deficiency could cause or exacerbate panniculitis in dogs.

Design

Cross-sectional, descriptive study.

Animals

9 dogs (5 with multiple lesions and 4 with solitary lesions).

Procedure

Serum samples were obtained by means of cephalic or jugular venipuncture and frozen at −20 C until assayed. Serum α1AT concentration was measured by means of radial gel immunodiffusion.

Results

In all dogs, serum α1AT concentration was within the previously established reference range.

Clinical Implications

In the small number of dogs studied, panniculitis was not associated with serum α1AT deficiency. (J Am Vet Med Assoc 1996;209:1582–1584)

Objective

To measure serum α1-antitrypsin (α1AT) concentration in dogs with histologically confirmed panniculitis to determine whether serum deficiency could cause or exacerbate panniculitis in dogs.

Design

Cross-sectional, descriptive study.

Animals

9 dogs (5 with multiple lesions and 4 with solitary lesions).

Procedure

Serum samples were obtained by means of cephalic or jugular venipuncture and frozen at −20 C until assayed. Serum α1AT concentration was measured by means of radial gel immunodiffusion.

Results

In all dogs, serum α1AT concentration was within the previously established reference range.

Clinical Implications

In the small number of dogs studied, panniculitis was not associated with serum α1AT deficiency. (J Am Vet Med Assoc 1996;209:1582–1584)

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