Ability of flumazenil, butorphanol, and naloxone to reverse the anesthetic effects of oxymorphone-diazepam in dogs

K. A. Lemke From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine. University of Illinois. Urbana, II., 61801.

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 DVM, MS
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W. J. Tranquilli From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine. University of Illinois. Urbana, II., 61801.

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 DVM, MS
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J. C. Thurmon From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine. University of Illinois. Urbana, II., 61801.

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 DVM, MS
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G. J. Benson From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine. University of Illinois. Urbana, II., 61801.

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W. A. Olson From the Department of Veterinary Clinical Medicine, College of Veterinary Medicine. University of Illinois. Urbana, II., 61801.

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 PhD

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Objective

To evaluate the ability of flumazenil (FLU), butorphanol (BUT), and naloxone (NAL) to reverse the anesthetic effects of oxymorphone-diazepam in dogs.

Animals

6 healthy adult mixed-breed dogs.

Procedure

Dogs were randomly assigned to each of 6 reversal treatment groups. In each experiment, oxymorphone (0.22 mg/kg of body weight, IV) and diazepam (0.22 mg/kg, IV) were given sequentially 15 minutes after glycopyrroiate (0.01 mg/kg, IV) administration. Physiologic saline solution (SAL; 1 ml), FLU (0.01 mg/kg), BUT (0.44 mg/kg), or NAL (0.06 mg/kg) alone, or FLU-BUT or FLU-NAL (same dosages) was given IV as a reversal treatment 15 minutes after oxymorphone-diazepam administration. An individual unaware of the treatment protocol recorded time to extubation, sternal recumbency, and walking.

Results

Time to extubation was significantly (P < 0.05) less with BUT, NAL, FLU-BUT, or FLU-NAL treatment, compared with that for SAL treatment. Time to sternal recumbency was less with BUT, NAL, FLU-BUT, or FLU-NAL treatment, compared with that for SAL treatment. Time to walking was less with FLU-BUT or FLU-NAL treatment, compared with that for SAL treatment.

Clinical Implications

Flumazenil, in combination with BUT or NAL, can be used to reverse the anesthetic effects of oxymorphone-diazepam in dogs. (J Am Vet Med Assoc 1996;209:776–779)

Objective

To evaluate the ability of flumazenil (FLU), butorphanol (BUT), and naloxone (NAL) to reverse the anesthetic effects of oxymorphone-diazepam in dogs.

Animals

6 healthy adult mixed-breed dogs.

Procedure

Dogs were randomly assigned to each of 6 reversal treatment groups. In each experiment, oxymorphone (0.22 mg/kg of body weight, IV) and diazepam (0.22 mg/kg, IV) were given sequentially 15 minutes after glycopyrroiate (0.01 mg/kg, IV) administration. Physiologic saline solution (SAL; 1 ml), FLU (0.01 mg/kg), BUT (0.44 mg/kg), or NAL (0.06 mg/kg) alone, or FLU-BUT or FLU-NAL (same dosages) was given IV as a reversal treatment 15 minutes after oxymorphone-diazepam administration. An individual unaware of the treatment protocol recorded time to extubation, sternal recumbency, and walking.

Results

Time to extubation was significantly (P < 0.05) less with BUT, NAL, FLU-BUT, or FLU-NAL treatment, compared with that for SAL treatment. Time to sternal recumbency was less with BUT, NAL, FLU-BUT, or FLU-NAL treatment, compared with that for SAL treatment. Time to walking was less with FLU-BUT or FLU-NAL treatment, compared with that for SAL treatment.

Clinical Implications

Flumazenil, in combination with BUT or NAL, can be used to reverse the anesthetic effects of oxymorphone-diazepam in dogs. (J Am Vet Med Assoc 1996;209:776–779)

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