Systemic arterial blood pressure and urine protein/creatinine ratio in dogs with hyperadrenocorticism

Theresa M. Ortega From the Veterinary Medical Teaching Hospital (Ortega) and the Department of Medicine (Feldman, Nelson, Cowgill), School of Veterinary Medicine, and the Division of Statistics (Willits), University of California, Davis, CA 95616.

Search for other papers by Theresa M. Ortega in
Current site
Google Scholar
PubMed
Close
 DVM
,
Edward C. Feldman From the Veterinary Medical Teaching Hospital (Ortega) and the Department of Medicine (Feldman, Nelson, Cowgill), School of Veterinary Medicine, and the Division of Statistics (Willits), University of California, Davis, CA 95616.

Search for other papers by Edward C. Feldman in
Current site
Google Scholar
PubMed
Close
 DVM
,
Richard W. Nelson From the Veterinary Medical Teaching Hospital (Ortega) and the Department of Medicine (Feldman, Nelson, Cowgill), School of Veterinary Medicine, and the Division of Statistics (Willits), University of California, Davis, CA 95616.

Search for other papers by Richard W. Nelson in
Current site
Google Scholar
PubMed
Close
 DVM
,
Neil Willits From the Veterinary Medical Teaching Hospital (Ortega) and the Department of Medicine (Feldman, Nelson, Cowgill), School of Veterinary Medicine, and the Division of Statistics (Willits), University of California, Davis, CA 95616.

Search for other papers by Neil Willits in
Current site
Google Scholar
PubMed
Close
 PhD
, and
Larry D. Cowgill From the Veterinary Medical Teaching Hospital (Ortega) and the Department of Medicine (Feldman, Nelson, Cowgill), School of Veterinary Medicine, and the Division of Statistics (Willits), University of California, Davis, CA 95616.

Search for other papers by Larry D. Cowgill in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Click on author name to view affiliation information

Objective—

To determine prevalence and severity of systemic arterial hypertension and proteinuria in dogs with naturally developing hyperadrenocorticism and to determine whether these abnormalities resolve with adequate management of the disease.

Design—

Case series and cohort study.

Animals—

77 dogs with naturally developing hyperadrenocorticism examined once; 15 dogs examined before and after treatment.

Results—

Among dogs examined only once, hypertension was diagnosed in 21 of 26 dogs with untreated pituitary-dependent hyperadrenocorticism (PDH), 17 of 21 with inadequately controlled PDH, 8 of 16 with well-controlled PDH, 10 of 10 with an untreated adrenocortical tumor, and 0 of 4 that had undergone adrenalectomy because of an adrenocortical tumor. Untreated dogs and dogs with inadequately controlled PDH had significantly higher blood pressures than did other dogs. Proteinuria was documented in 12 of 26 dogs with untreated PDH, 5 of 16 with inadequately controlled PDH, 3 of 14 with well-controlled PDH, 5 of 8 with an untreated adrenocortical tumor, and 1 of 3 that had undergone adrenalectomy. Dogs with untreated PDH and dogs with an untreated adrenocortical tumor had higher urine protein/creatinine ratios than did dogs with well-controlled PDH. Among dogs evaluated before and after treatment, blood pressure and urine protein/creatinine ratio did not change in 8 dogs with inadequately controlled hyperadrenocorticism, but decreased in 7 dogs with well-controlled disease.

Clinical Implications—

Results suggest that systemic hypertension and proteinuria are common in dogs with untreated hyperadrenocorticism and that successful treatment of hyperadrenocorticism will result in resolution of these abnormalities in many, but not all, dogs. (J Am Vet Med Assoc 1996;209:1724–1729)

Objective—

To determine prevalence and severity of systemic arterial hypertension and proteinuria in dogs with naturally developing hyperadrenocorticism and to determine whether these abnormalities resolve with adequate management of the disease.

Design—

Case series and cohort study.

Animals—

77 dogs with naturally developing hyperadrenocorticism examined once; 15 dogs examined before and after treatment.

Results—

Among dogs examined only once, hypertension was diagnosed in 21 of 26 dogs with untreated pituitary-dependent hyperadrenocorticism (PDH), 17 of 21 with inadequately controlled PDH, 8 of 16 with well-controlled PDH, 10 of 10 with an untreated adrenocortical tumor, and 0 of 4 that had undergone adrenalectomy because of an adrenocortical tumor. Untreated dogs and dogs with inadequately controlled PDH had significantly higher blood pressures than did other dogs. Proteinuria was documented in 12 of 26 dogs with untreated PDH, 5 of 16 with inadequately controlled PDH, 3 of 14 with well-controlled PDH, 5 of 8 with an untreated adrenocortical tumor, and 1 of 3 that had undergone adrenalectomy. Dogs with untreated PDH and dogs with an untreated adrenocortical tumor had higher urine protein/creatinine ratios than did dogs with well-controlled PDH. Among dogs evaluated before and after treatment, blood pressure and urine protein/creatinine ratio did not change in 8 dogs with inadequately controlled hyperadrenocorticism, but decreased in 7 dogs with well-controlled disease.

Clinical Implications—

Results suggest that systemic hypertension and proteinuria are common in dogs with untreated hyperadrenocorticism and that successful treatment of hyperadrenocorticism will result in resolution of these abnormalities in many, but not all, dogs. (J Am Vet Med Assoc 1996;209:1724–1729)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 277 277 113
PDF Downloads 86 86 24
Advertisement