Radiotherapy of oral malignant melanomas in dogs
L. Blackwood
BVMS, MVM
L. Blackwood
From The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Rd, Cambridge, CB3 OES, England.
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J. M. Dobson
MA, DVetMed
J. M. Dobson
From The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Rd, Cambridge, CB3 OES, England.
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Objective
To evaluate response to radiotherapy in dogs with oral malignant melanomas.
Design
Clinical trial.
Animals
36 dogs with histologically confirmed oral malignant melanomas.
Procedure
The prescribed radiation dose was 36 Gy given in 4 fractions of 9 Gy at 7-day intervals. The primary radiation source was a linear accelerator.
Results
In 25 of 36 dogs, complete remission was achieved, and in 9 dogs, partial remission was achieved. Recurrence of the primary tumor was the cause of euthanasia of 4 dogs. Twenty-one dogs were euthanatized because of metastasis.
Clinical Implications
Radiotherapy was an effective palliative treatment for the primary tumor in dogs with oral malignant melanomas. However, rapid development of metastatic disease remained a major challenge, (J Am Vet Med Assoc 1996;209:98–102)
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