Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses

C. K. Clark From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136 (Clark, Merritt, Burrow), and the Institute of Food and Agricultural Sciences, Department of Statistics, 401 Rolfs Hall, PO Box 110560, University of Florida, Gainesville, FL 32611-0560 (Steible).

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A. M. Merritt From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136 (Clark, Merritt, Burrow), and the Institute of Food and Agricultural Sciences, Department of Statistics, 401 Rolfs Hall, PO Box 110560, University of Florida, Gainesville, FL 32611-0560 (Steible).

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J. A. Burrow From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136 (Clark, Merritt, Burrow), and the Institute of Food and Agricultural Sciences, Department of Statistics, 401 Rolfs Hall, PO Box 110560, University of Florida, Gainesville, FL 32611-0560 (Steible).

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C. K. Steible From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0136 (Clark, Merritt, Burrow), and the Institute of Food and Agricultural Sciences, Department of Statistics, 401 Rolfs Hall, PO Box 110560, University of Florida, Gainesville, FL 32611-0560 (Steible).

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Objective

To assess the effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in clinically normal horses and to develop guidelines on the use of these agents for treatment of peptic ulcer disease in horses.

Design

Prospective, randomized, controlled trial.

Animals

5 clinically normal adult horses with chronically implanted gastric cannulas.

Procedure

Each horse received all 5 treatments (30 g of aluminum hydroxide/15 g of magnesium hydroxide, 12 g of aluminum hydroxide/6 g of magnesium hydroxide, 10.5 g of bismuth subsalicylate, 26.25 g of bismuth subsalicylate, and 5% methylcellulose control) with only 1 experiment performed each day. Gastric pH was measured via a glass electrode inserted through the gastric cannula for 1 hour before treatment and continued for 2 hours after treatment. Food or water was not given to the horses during the experiment. Measurements of gastric pH obtained during posttreatment hours were compared with pretreatment gastric pH values.

Results

Only a dose of 30 g of aluminum hydroxide/ 15 g of magnesium hydroxide resulted in a significant increase in gastric pH over baseline or control values. Mean pH was 5.2 ± 0.62 and 4.59 ± 0.48 for posttreatment hours 1 and 2, respectively.

Clinical Implications

Oral administration of 30 g of aluminum hydroxide/15 g of magnesium hydroxide to adult horses should result in a mean hourly gastric pH ≥ 4.0 for at least 2 hours. (J Am Vet Med Assoc 1996;208:1687-1691)

Objective

To assess the effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in clinically normal horses and to develop guidelines on the use of these agents for treatment of peptic ulcer disease in horses.

Design

Prospective, randomized, controlled trial.

Animals

5 clinically normal adult horses with chronically implanted gastric cannulas.

Procedure

Each horse received all 5 treatments (30 g of aluminum hydroxide/15 g of magnesium hydroxide, 12 g of aluminum hydroxide/6 g of magnesium hydroxide, 10.5 g of bismuth subsalicylate, 26.25 g of bismuth subsalicylate, and 5% methylcellulose control) with only 1 experiment performed each day. Gastric pH was measured via a glass electrode inserted through the gastric cannula for 1 hour before treatment and continued for 2 hours after treatment. Food or water was not given to the horses during the experiment. Measurements of gastric pH obtained during posttreatment hours were compared with pretreatment gastric pH values.

Results

Only a dose of 30 g of aluminum hydroxide/ 15 g of magnesium hydroxide resulted in a significant increase in gastric pH over baseline or control values. Mean pH was 5.2 ± 0.62 and 4.59 ± 0.48 for posttreatment hours 1 and 2, respectively.

Clinical Implications

Oral administration of 30 g of aluminum hydroxide/15 g of magnesium hydroxide to adult horses should result in a mean hourly gastric pH ≥ 4.0 for at least 2 hours. (J Am Vet Med Assoc 1996;208:1687-1691)

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