Response to high-dose radioactive iodine administration in cats with thyroid carcinoma that had previously undergone surgery

Lynn Guptill From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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 MS, DVM
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J. Catharine From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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R. Scott-Moncrieff From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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 MA, VetMB, MS
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Evan B. Janovitz From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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William E. Blevins From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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Susan E. Yohn From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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Dennis B. DeNicola From the Departments of Veterinary Clinical Sciences (Guptill, Scott-Moncrieff, Blevins, Yohn) and Veterinary Pathobiology (Janovitz, DeNicola), School of Veterinary Medicine, Purdue University, West Lafayette, IN 49707.

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Summary

Seven cats with thyroid carcinomas that had previously undergone surgical removal of neoplastic tissue were treated with 30 mCi of radioactive iodine (131I). Six of the cats had clinical signs of hyperthyroidism; 1 did not. There were no complications associated with 131I treatment, and clinical signs resolved in all cats. Technetium scans of 4 cats made after treatment did not have evidence of isotope uptake. In the remaining 3 cats, small areas of isotope uptake, the intensity of which was equal to or less than the intensity of uptake in the salivary glands, were seen. All 7 cats became hypothyroid after treatment; 4 required L-thyroxine supplementation. One cat was alive 33 months after treatment. The other 6 cats were euthanatized because of unrelated diseases 10 to 41 months after treatment.

Summary

Seven cats with thyroid carcinomas that had previously undergone surgical removal of neoplastic tissue were treated with 30 mCi of radioactive iodine (131I). Six of the cats had clinical signs of hyperthyroidism; 1 did not. There were no complications associated with 131I treatment, and clinical signs resolved in all cats. Technetium scans of 4 cats made after treatment did not have evidence of isotope uptake. In the remaining 3 cats, small areas of isotope uptake, the intensity of which was equal to or less than the intensity of uptake in the salivary glands, were seen. All 7 cats became hypothyroid after treatment; 4 required L-thyroxine supplementation. One cat was alive 33 months after treatment. The other 6 cats were euthanatized because of unrelated diseases 10 to 41 months after treatment.

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