Evaluation of urinary cortisol:creatinine ratios for the diagnosis of hyperadrenocorticism associated with adrenal gland tumors in ferrets

Willard J. Gould From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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Thomas J. Reimers From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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Judith A. Bell From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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Howard J. Lawrence From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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John F. Randolph From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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Peter H. Rowland From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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Janet M. Scarlett From the Departments of Clinical Sciences (Gould, Lawrence, Randolph, Scarlett), Diagnostic Laboratory (Reimers) and Pathology (Rowland), College of Veterinary Medicine, Cornell University, Ithaca, NY 14853; and Marshall Farms, North Rose, NY 14516 (Bell).

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Summary

Assays were validated for the measurement of urinary concentrations of cortisol and creatinine in domestic ferrets (Mustela putorius furo). Urinary concentrations of cortisol and creatinine and the calculated urinary cortisol:creatinine ratio (UCCR) values were determined for 29 clinically normal female ferrets, 22 clinically normal male ferrets, and 12 ferrets with adrenal gland tumors. The UCCR values for the 51 clinically normal ferrets ranged from 0.04 × 10-6 to 1.66 × 10-6, with a median value of 0.22 × 10-6. The UCCR values were significantly (P ≤ 0.01) higher in the 12 ferrets with adrenal tumors, with a range of 0.5 × 10-6 to 60.13 × 10-6 and a median of 5.98 × 10-6. We concluded that determination of UCCR values was useful in the diagnosis of hyperadrenocorticism associated with adrenal neoplasia in domestic ferrets.

Summary

Assays were validated for the measurement of urinary concentrations of cortisol and creatinine in domestic ferrets (Mustela putorius furo). Urinary concentrations of cortisol and creatinine and the calculated urinary cortisol:creatinine ratio (UCCR) values were determined for 29 clinically normal female ferrets, 22 clinically normal male ferrets, and 12 ferrets with adrenal gland tumors. The UCCR values for the 51 clinically normal ferrets ranged from 0.04 × 10-6 to 1.66 × 10-6, with a median value of 0.22 × 10-6. The UCCR values were significantly (P ≤ 0.01) higher in the 12 ferrets with adrenal tumors, with a range of 0.5 × 10-6 to 60.13 × 10-6 and a median of 5.98 × 10-6. We concluded that determination of UCCR values was useful in the diagnosis of hyperadrenocorticism associated with adrenal neoplasia in domestic ferrets.

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