Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988–1992)

Lisa A. Fortier From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Fortier), and the Illinois Equine Hospital, Naperville, 1L 60563 (Mac Harg).

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Margaret A. Mac Harg From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Fortier), and the Illinois Equine Hospital, Naperville, 1L 60563 (Mac Harg).

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Summary

Ten horses with histologically confirmed squamous cell carcinoma (scc) and 1 horse with presumptive scc of the external genitalia were treated with a combination of surgical debridement and topical administration of 5-fluorouracil, or with topical treatment alone. Tumor remission was obtained in all horses except 1 in which owner compliance was deficient, and no recurrences have been reported. Topical use of 5-fluorouracil as a chemotherapeutic agent for treatment of genital lesions of scc in horses should be considered as a viable alternative to radical surgical excision.

Summary

Ten horses with histologically confirmed squamous cell carcinoma (scc) and 1 horse with presumptive scc of the external genitalia were treated with a combination of surgical debridement and topical administration of 5-fluorouracil, or with topical treatment alone. Tumor remission was obtained in all horses except 1 in which owner compliance was deficient, and no recurrences have been reported. Topical use of 5-fluorouracil as a chemotherapeutic agent for treatment of genital lesions of scc in horses should be considered as a viable alternative to radical surgical excision.

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