Urinary α-amylase and serum macroamylase activities in dogs with proteinuria

Michele Corazza From the Facolta di Medicina Veterinaria, Istituto di Patologia Speciale e Clinica Medica, V.le delle Piagge, 2 56100 Pisa, Italy.

Search for other papers by Michele Corazza in
Current site
Google Scholar
PubMed
Close
 DVM
,
Rosalba Tognetti From the Facolta di Medicina Veterinaria, Istituto di Patologia Speciale e Clinica Medica, V.le delle Piagge, 2 56100 Pisa, Italy.

Search for other papers by Rosalba Tognetti in
Current site
Google Scholar
PubMed
Close
 DVM
,
Grazia Guidi From the Facolta di Medicina Veterinaria, Istituto di Patologia Speciale e Clinica Medica, V.le delle Piagge, 2 56100 Pisa, Italy.

Search for other papers by Grazia Guidi in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Alfredo Buonaccorsi From the Facolta di Medicina Veterinaria, Istituto di Patologia Speciale e Clinica Medica, V.le delle Piagge, 2 56100 Pisa, Italy.

Search for other papers by Alfredo Buonaccorsi in
Current site
Google Scholar
PubMed
Close
 DVM

Summary

Activities of urinary α-amylase and serum macroamylase; concentrations of serum creatinine, immunocomplexes, and urinary protein; and patterns of proteinuria were determined in 35 dogs with proteinuria. Urinary α-amylase activity ranged from 37 to 4,031 U/L. Macroamylasemia was detected in 77.14% of dogs and the percentage of α-amylase precipitated ranged from 4.68 to 61.63. Serum α-amylase activity after immunoglobulin precipitation ranged from 654 to 6,390 U/L in 51.42% of the dogs; the values were higher than the reference limits. Concentrations of serum creatinine and immunocomplexes were higher than reference limits for 25.71 and 60% of dogs, respectively. Urinary protein concentrations ranged from 0.1 to 8.9 g/L· All the patterns of proteinuria were represented. Linear regression indicated correlations between urinary α-amylase activities, serum creatinine concentrations (P < 0.01), and concentration of immunocomplexes (P < 0.05). Mann-Whitney test indicated significantly higher urinary α-amylase activity (P < 0.02) and percentage of α-amylase precipitated (P < 0.05) in dogs with renal insufficiency.

Summary

Activities of urinary α-amylase and serum macroamylase; concentrations of serum creatinine, immunocomplexes, and urinary protein; and patterns of proteinuria were determined in 35 dogs with proteinuria. Urinary α-amylase activity ranged from 37 to 4,031 U/L. Macroamylasemia was detected in 77.14% of dogs and the percentage of α-amylase precipitated ranged from 4.68 to 61.63. Serum α-amylase activity after immunoglobulin precipitation ranged from 654 to 6,390 U/L in 51.42% of the dogs; the values were higher than the reference limits. Concentrations of serum creatinine and immunocomplexes were higher than reference limits for 25.71 and 60% of dogs, respectively. Urinary protein concentrations ranged from 0.1 to 8.9 g/L· All the patterns of proteinuria were represented. Linear regression indicated correlations between urinary α-amylase activities, serum creatinine concentrations (P < 0.01), and concentration of immunocomplexes (P < 0.05). Mann-Whitney test indicated significantly higher urinary α-amylase activity (P < 0.02) and percentage of α-amylase precipitated (P < 0.05) in dogs with renal insufficiency.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 690 662 32
PDF Downloads 57 46 5
Advertisement