Plasma von Willebrand factor antigen concentration in dogs with hypothyroidism

David L. Panciera From the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706 (Panciera), and the Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211 (Johnson).

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 DVM, MS
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Gary S. Johnson From the Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706 (Panciera), and the Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211 (Johnson).

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 DVM, PhD

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Summary

Plasma von Willebrand factor antigen concentration was measured in 10 dogs with hypothyroidism, before and after administration of a replacement dose of levothyroxine for 67 ± 12 days. Results were reported as a percentage of normal activity, with plasma pooled from clinically normal dogs given a value of 100%. Plasma von Willebrand factor antigen concentration was within reference limits in dogs with hypothyroidism (126 ± 41%) and was significantly (P < 0.01) decreased (94 ± 39%) after treatment with levothyroxine. Contrary to findings in some other studies, a deficiency of plasma von Willebrand factor did not appear to result from hypothyroidism.

Summary

Plasma von Willebrand factor antigen concentration was measured in 10 dogs with hypothyroidism, before and after administration of a replacement dose of levothyroxine for 67 ± 12 days. Results were reported as a percentage of normal activity, with plasma pooled from clinically normal dogs given a value of 100%. Plasma von Willebrand factor antigen concentration was within reference limits in dogs with hypothyroidism (126 ± 41%) and was significantly (P < 0.01) decreased (94 ± 39%) after treatment with levothyroxine. Contrary to findings in some other studies, a deficiency of plasma von Willebrand factor did not appear to result from hypothyroidism.

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