Evaluation of a feline leukemia virus vaccine in a controlled natural transmission study

Louis J. Lafrado From the Center for Retrovirus Research, Department of Veterinary Pathobiology, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Rd, Columbus, OH 43210. Dr. Lafrado’s present address is The Coulston Foundation, Bldg 1264, PO Box 1027, Holloman Air Force Base, NM 88330.

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Abstract

Twenty-six 8-week-old specific-pathogen-free cats were vaccinated subcutaneously with 2 doses of a commercially available FeLV vaccine, and 26 age-matched specific-pathogen-free cats were similarly vaccinated with a placebo vaccine containing the same adjuvant as the FeLV vaccine. Cats then were randomly assigned to 2 groups of 26 cats (13 FeLV-vaccinated cats and 13 control cats), and each group was housed with 5 cats previously inoculated with FeLV. AU cats were tested biweekly for the next 26 weeks for evidence of FeLV antigenemia. Five of the 26 control cats developed antigenemia. However, 4 of these cats were only transiently antigénémie (positive results for 3 consecutive biweekly samples) and only 1 was persistently antigénémie. None of the FeLV-vaccinated cats developed antigenemia. Preventable fraction was calculated to be 100%.

Abstract

Twenty-six 8-week-old specific-pathogen-free cats were vaccinated subcutaneously with 2 doses of a commercially available FeLV vaccine, and 26 age-matched specific-pathogen-free cats were similarly vaccinated with a placebo vaccine containing the same adjuvant as the FeLV vaccine. Cats then were randomly assigned to 2 groups of 26 cats (13 FeLV-vaccinated cats and 13 control cats), and each group was housed with 5 cats previously inoculated with FeLV. AU cats were tested biweekly for the next 26 weeks for evidence of FeLV antigenemia. Five of the 26 control cats developed antigenemia. However, 4 of these cats were only transiently antigénémie (positive results for 3 consecutive biweekly samples) and only 1 was persistently antigénémie. None of the FeLV-vaccinated cats developed antigenemia. Preventable fraction was calculated to be 100%.

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