Effect of oxytetracycline on metacarpophalangeal and distal interphalangeal joint angles in newborn foals

John B. Madison From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine (Madison, Garber, Rice, Stumf, Zimmer) and Animal Science (Ott), University of Florida, PO Box 100136, Gainesville, FL 32610-0136.

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Jenifer L. Garber From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine (Madison, Garber, Rice, Stumf, Zimmer) and Animal Science (Ott), University of Florida, PO Box 100136, Gainesville, FL 32610-0136.

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Brett Rice From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine (Madison, Garber, Rice, Stumf, Zimmer) and Animal Science (Ott), University of Florida, PO Box 100136, Gainesville, FL 32610-0136.

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Annette J. Stumf From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine (Madison, Garber, Rice, Stumf, Zimmer) and Animal Science (Ott), University of Florida, PO Box 100136, Gainesville, FL 32610-0136.

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Allison E. Zimmer From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine (Madison, Garber, Rice, Stumf, Zimmer) and Animal Science (Ott), University of Florida, PO Box 100136, Gainesville, FL 32610-0136.

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Edgar A. Ott From the Department of Large Animal Clinical Sciences, College of Veterinary Medicine (Madison, Garber, Rice, Stumf, Zimmer) and Animal Science (Ott), University of Florida, PO Box 100136, Gainesville, FL 32610-0136.

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Summary

Thirty-five newborn foals were assigned to 1 of 3 groups and treated with 0.9% NaCl solution (saline; group 1; n = 12), oxytetracycline (44 mg/kg of body weight; group 2; n = 12), or 2-pyrrolidone (oxytetracycline vehicle; group 3; n = 11) in saline solution during the first 36 hours after birth. Serum biochemical analyses were performed on samples obtained from group-1 and group-2 foals before treatment and 24 and 96 hours after treatment. Lateral to medial radiographic views of the forelimbs were obtained before treatment and 24 and 96 hours after treatment in all foals. Metacarpophalangeal and distal interphalangeal joint angles were measured from the radiographic images. Significant changes in blood chemistry values, other than those typically observed in newborn foals, were not detected. A significant decrease in mean metacarpophalangeal joint angle was observed in foals 24 hours after treatment with oxytetracycline, compared with that in foals of groups 1 and 3. The mean metacarpophalangeal joint angle returned to pretreatment values by 96 hours. Oxytetracycline appears to be an effective method for obtaining a short-term moderate decrease in metacarpophalangeal joint angle in newborn foals.

Summary

Thirty-five newborn foals were assigned to 1 of 3 groups and treated with 0.9% NaCl solution (saline; group 1; n = 12), oxytetracycline (44 mg/kg of body weight; group 2; n = 12), or 2-pyrrolidone (oxytetracycline vehicle; group 3; n = 11) in saline solution during the first 36 hours after birth. Serum biochemical analyses were performed on samples obtained from group-1 and group-2 foals before treatment and 24 and 96 hours after treatment. Lateral to medial radiographic views of the forelimbs were obtained before treatment and 24 and 96 hours after treatment in all foals. Metacarpophalangeal and distal interphalangeal joint angles were measured from the radiographic images. Significant changes in blood chemistry values, other than those typically observed in newborn foals, were not detected. A significant decrease in mean metacarpophalangeal joint angle was observed in foals 24 hours after treatment with oxytetracycline, compared with that in foals of groups 1 and 3. The mean metacarpophalangeal joint angle returned to pretreatment values by 96 hours. Oxytetracycline appears to be an effective method for obtaining a short-term moderate decrease in metacarpophalangeal joint angle in newborn foals.

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