Clinical efficacy of milbemycin oxime in the treatment of generalized demodicosis in adult dogs

William H. Miller Jr. From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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Danny W. Scott From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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Jocelyn R. Wellington From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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Rada Panić From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

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Summary

Thirty adult dogs with chronic generalized demodicosis were treated with oral administration of milbemycin oxime (0.52 to 3.8 mg/kg oj body weight, q 24 h). Results oj skin scrapings were used to determine whether administration oj milbemycin should be continued or discontinued. Dogs that were free of clinical signs of demodicosis 12 months after administration of milbemycin was discontinued were considered cured. Sixteen dogs were cured, 5 dogs were never cleared of mites, and 9 dogs were cleared of mites, but relapsed after administration of milbemycin was discontinued. Adverse effects of milbemycin were rare and transient.

Summary

Thirty adult dogs with chronic generalized demodicosis were treated with oral administration of milbemycin oxime (0.52 to 3.8 mg/kg oj body weight, q 24 h). Results oj skin scrapings were used to determine whether administration oj milbemycin should be continued or discontinued. Dogs that were free of clinical signs of demodicosis 12 months after administration of milbemycin was discontinued were considered cured. Sixteen dogs were cured, 5 dogs were never cleared of mites, and 9 dogs were cleared of mites, but relapsed after administration of milbemycin was discontinued. Adverse effects of milbemycin were rare and transient.

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