Effect of sucralfate on healing of subclinical gastric ulcers in foals

Agatha T. Borne From the Department of Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078.

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Charles G. MacAllister From the Department of Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078.

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Summary:

The effect of sucralfate on healing of subclinical gastric ulcers and gastric inflammation was investigated in twelve 6- to 7-month-old foals. Foals with endoscopically evident gastric lesions on day 0 were assigned to 1 of 2 groups, on the basis of mucosal inflammation and number and severity of ulcers, to create groups of foals with approximately equal severity of lesions. None of these foals had clinical signs of gastroduodenal ulcer disease. Groups were assigned to receive sucralfate (22.0 mg/kg of body weight) or corn syrup for 14 days, po, every 8 hours. On day 15, gastroscopic examinations revealed that sucralfate did not promote greater healing than did the corn syrup.

Summary:

The effect of sucralfate on healing of subclinical gastric ulcers and gastric inflammation was investigated in twelve 6- to 7-month-old foals. Foals with endoscopically evident gastric lesions on day 0 were assigned to 1 of 2 groups, on the basis of mucosal inflammation and number and severity of ulcers, to create groups of foals with approximately equal severity of lesions. None of these foals had clinical signs of gastroduodenal ulcer disease. Groups were assigned to receive sucralfate (22.0 mg/kg of body weight) or corn syrup for 14 days, po, every 8 hours. On day 15, gastroscopic examinations revealed that sucralfate did not promote greater healing than did the corn syrup.

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