Lymphoma involving large granular lymphocytes in cats: 11 cases (1982-1991)

Maxey L. Wellman From the Departments of Veterinary Pathobiology (Wellman, Kociba, Rojko) and Veterinary Clinical Sciences (Hammer, DiBartola), College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 and Internal Medicine Referral Practice of Cleveland (Carothers), Bedford Heights, OH 44146.

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Alan S. Hammer From the Departments of Veterinary Pathobiology (Wellman, Kociba, Rojko) and Veterinary Clinical Sciences (Hammer, DiBartola), College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 and Internal Medicine Referral Practice of Cleveland (Carothers), Bedford Heights, OH 44146.

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Stephen P. DiBartola From the Departments of Veterinary Pathobiology (Wellman, Kociba, Rojko) and Veterinary Clinical Sciences (Hammer, DiBartola), College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 and Internal Medicine Referral Practice of Cleveland (Carothers), Bedford Heights, OH 44146.

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Marcia A. Carothers From the Departments of Veterinary Pathobiology (Wellman, Kociba, Rojko) and Veterinary Clinical Sciences (Hammer, DiBartola), College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 and Internal Medicine Referral Practice of Cleveland (Carothers), Bedford Heights, OH 44146.

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Gary J. Kociba From the Departments of Veterinary Pathobiology (Wellman, Kociba, Rojko) and Veterinary Clinical Sciences (Hammer, DiBartola), College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 and Internal Medicine Referral Practice of Cleveland (Carothers), Bedford Heights, OH 44146.

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Jennifer L. Rojko From the Departments of Veterinary Pathobiology (Wellman, Kociba, Rojko) and Veterinary Clinical Sciences (Hammer, DiBartola), College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 and Internal Medicine Referral Practice of Cleveland (Carothers), Bedford Heights, OH 44146.

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Summary

Medical records of 11 cats with lymphoma involving large granular lymphocytes were reviewed. All 9 cats tested were FeLV-negative. Ten cats had a history of anorexia, lethargy, vomiting, or diarrhea, and had lymphoma involving abdominal viscera. The most common site of tumor in these cats was the jejunum. One cat had cutaneous masses caused by dermal and epidermal infiltration with neoplastic large granular lymphocytes. The most common hematologic abnormality was leukocytosis, characterized by neutrophilia with a left shift (7 cats); 2 cats had a left shift without neutrophilia. None of the cats had lymphocytosis, but immature large granular lymphocytes were found in the blood of 4 cats. The most common serum biochemical abnormalities were hypoalbuminemia (10 cats), hypocalcemia (10 cats), hypoproteinemia (9 cats), high aspartate transaminase activity (9 cats), and hyperbilirubinemia (8 cats).

Large granular lymphocytes were characterized by abundant cytoplasm containing distinct azurophilic granules that varied in size and number. The most common cytochemical staining pattern included detection of α-naphthyl butyrate esterase, acid phosphatase, and β-glucuronidase activities. On examination of histologic sections, granules stained weakly eosinophilic with Giemsa and moderately with periodic acid-Schiff reaction. Ultrastructurally, the granules appeared membrane bound and contained an electron-dense matrix in 4 cats.

Summary

Medical records of 11 cats with lymphoma involving large granular lymphocytes were reviewed. All 9 cats tested were FeLV-negative. Ten cats had a history of anorexia, lethargy, vomiting, or diarrhea, and had lymphoma involving abdominal viscera. The most common site of tumor in these cats was the jejunum. One cat had cutaneous masses caused by dermal and epidermal infiltration with neoplastic large granular lymphocytes. The most common hematologic abnormality was leukocytosis, characterized by neutrophilia with a left shift (7 cats); 2 cats had a left shift without neutrophilia. None of the cats had lymphocytosis, but immature large granular lymphocytes were found in the blood of 4 cats. The most common serum biochemical abnormalities were hypoalbuminemia (10 cats), hypocalcemia (10 cats), hypoproteinemia (9 cats), high aspartate transaminase activity (9 cats), and hyperbilirubinemia (8 cats).

Large granular lymphocytes were characterized by abundant cytoplasm containing distinct azurophilic granules that varied in size and number. The most common cytochemical staining pattern included detection of α-naphthyl butyrate esterase, acid phosphatase, and β-glucuronidase activities. On examination of histologic sections, granules stained weakly eosinophilic with Giemsa and moderately with periodic acid-Schiff reaction. Ultrastructurally, the granules appeared membrane bound and contained an electron-dense matrix in 4 cats.

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