Comparison of lidocaine, xylazine, and xylazine/lidocaine for caudal epidural analgesia in horses

T. L. Grubb From the Veterinary Teaching Hospital, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331.

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T. W. Riebold From the Veterinary Teaching Hospital, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331.

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M. J. Huber From the Veterinary Teaching Hospital, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331.

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Summary

Caudal epidural analgesia was achieved in 6 adult horses on 3 successive occasions at weekly intervals by injection of lidocaine, xylazine, and a combination of lidocaine/xylazine through indwelling epidural catheters. Analgesia was defined as a lack of response to pinprick and hemostat pressure in the skin of the perineal area. A significant (P < 0.05) difference was not found for time of onset of analgesia between lidocaine (4.3 ± 0.8 minutes, mean ± SEM) and the lidocaine/xylazine combination (5.3 ± 1.3 minutes). Time to onset of analgesia after administration of xylazine was significantly (P < 0.05) longer (32.0 ± 3.4 minutes) than that for either of the other 2 treatments. Duration of analgesia was significantly (P < 0.05) longer for the combination (329.8 ± 6.2 minutes) than for either drug used alone (lidocaine, 87.2 ± 7.5 minutes; xylazine, 204.2 ± 12.9 minutes). Pulse and respiratory rates were not significantly altered by any of the drugs. Neurologic sequelae were not clinically apparent after administration of the drugs or after chronic epidural catheterization.

Summary

Caudal epidural analgesia was achieved in 6 adult horses on 3 successive occasions at weekly intervals by injection of lidocaine, xylazine, and a combination of lidocaine/xylazine through indwelling epidural catheters. Analgesia was defined as a lack of response to pinprick and hemostat pressure in the skin of the perineal area. A significant (P < 0.05) difference was not found for time of onset of analgesia between lidocaine (4.3 ± 0.8 minutes, mean ± SEM) and the lidocaine/xylazine combination (5.3 ± 1.3 minutes). Time to onset of analgesia after administration of xylazine was significantly (P < 0.05) longer (32.0 ± 3.4 minutes) than that for either of the other 2 treatments. Duration of analgesia was significantly (P < 0.05) longer for the combination (329.8 ± 6.2 minutes) than for either drug used alone (lidocaine, 87.2 ± 7.5 minutes; xylazine, 204.2 ± 12.9 minutes). Pulse and respiratory rates were not significantly altered by any of the drugs. Neurologic sequelae were not clinically apparent after administration of the drugs or after chronic epidural catheterization.

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