Efficacy of ivermectin as an anthelmintic in leopard frogs

James Letcher From the Lincoln Park Zoological Gardens, 2200 N Cannon Dr, Chicago, IL 60614-3895 (Letcher) and the Department of Pharmacology, School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611-3009 (Glade).

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Michael Glade From the Lincoln Park Zoological Gardens, 2200 N Cannon Dr, Chicago, IL 60614-3895 (Letcher) and the Department of Pharmacology, School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611-3009 (Glade).
From the Lincoln Park Zoological Gardens, 2200 N Cannon Dr, Chicago, IL 60614-3895 (Letcher) and the Department of Pharmacology, School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611-3009 (Glade).

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Summary:

Ivermectin administered cutaneously at dosages of 2 mg/kg of body weight eliminated nematode infections in leopard frogs. Three clinical trials were conducted. In the first trial, 5 groups of 11 frogs were given ivermectin im at dosages of 0, 0.2, 0.4, 2, or 20 mg/kg. All frogs given ivermectin im at dosages of 2.0 mg/kg or greater died. In trial 2, 44 frogs, allotted to 5 groups, were given ivermectin cutaneously at 0, 0.2, 2, or 20 mg/kg. Cutaneously administered ivermectin was not toxic at dosages up to 20 mg/kg. In trial 3, nematode infections were eliminated in all 10 frogs treated cutaneously with ivermectin at 2.0 mg/kg.

Summary:

Ivermectin administered cutaneously at dosages of 2 mg/kg of body weight eliminated nematode infections in leopard frogs. Three clinical trials were conducted. In the first trial, 5 groups of 11 frogs were given ivermectin im at dosages of 0, 0.2, 0.4, 2, or 20 mg/kg. All frogs given ivermectin im at dosages of 2.0 mg/kg or greater died. In trial 2, 44 frogs, allotted to 5 groups, were given ivermectin cutaneously at 0, 0.2, 2, or 20 mg/kg. Cutaneously administered ivermectin was not toxic at dosages up to 20 mg/kg. In trial 3, nematode infections were eliminated in all 10 frogs treated cutaneously with ivermectin at 2.0 mg/kg.

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