Evaluation of survival times after limb amputation, with and without subsequent administration of cisplatin, for treatment of appendicular osteosarcoma in dogs: 30 cases (1979-1990)

James P. Thompson From the Department of Small Animal Clinical Sciences, Box J-126 Health Science Center, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610.

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Madonna J. Fugent From the Department of Small Animal Clinical Sciences, Box J-126 Health Science Center, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610.

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Summary

Appendicular osteosarcoma was diagnosed in 30 dogs. Fifteen dogs were treated by limb amputation alone, and 15 dogs were treated by limb amputation followed by 2 doses of cisplatin given iv approximately 2 and 7 weeks after limb removal. Mean survival time after limb amputation alone ± sd was 190 ± 138 days (median, 168 days); 7 dogs survived longer than 6 months, and 3 dogs survived more than 1 year. Fourteen of 15 dogs treated by amputation and administration of cisplatin survived a mean of 315 ± 158 days (median, 290 days) after amputation, and 1 dog was still alive at 1,095 days; 13 dogs survived longer than 6 months and 5 dogs survived more than 1 year. Survival time was significantly (P < 0.05) greater in dogs given cisplatin.

Summary

Appendicular osteosarcoma was diagnosed in 30 dogs. Fifteen dogs were treated by limb amputation alone, and 15 dogs were treated by limb amputation followed by 2 doses of cisplatin given iv approximately 2 and 7 weeks after limb removal. Mean survival time after limb amputation alone ± sd was 190 ± 138 days (median, 168 days); 7 dogs survived longer than 6 months, and 3 dogs survived more than 1 year. Fourteen of 15 dogs treated by amputation and administration of cisplatin survived a mean of 315 ± 158 days (median, 290 days) after amputation, and 1 dog was still alive at 1,095 days; 13 dogs survived longer than 6 months and 5 dogs survived more than 1 year. Survival time was significantly (P < 0.05) greater in dogs given cisplatin.

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