Diagnosis of microthrombocytosis and immune-mediated thrombocytopenia in dogs with thrombocytopenia: 68 cases (1987-1989)

J. Northern Jr. From the Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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 DVM, MS
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H. W. Tvedten From the Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824-1314.

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 DVM, PhD

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Summary

The mean platelet volume (mpv) was evaluated in 68 dogs with thrombocytopenia attributable to various causes. Platelet size was high or low in some dogs. The most clinically useful observation was that low mpv (microthrombocytosis) was a specific indicator of immune-mediated thrombocytopenia (imt) in these thrombocytopenic dogs. All but one case of microthrombocytosis (mpv< 5.4 fl) was found in dogs with imt. Microthrombocytosis was detected in 17 of 31 dogs with imt and appeared at the onset of the disease. Macrothrombocytosis (mpv > 9.4 fl) indicated active thrombopoiesis, but was not unique to any disease category. Macrothrombocytosis was detected in 18 of 31 dogs with imt, 3 of 17 dogs with disseminated intravascular coagulation, and 3 of 9 dogs with primary bone-marrow disease.

Summary

The mean platelet volume (mpv) was evaluated in 68 dogs with thrombocytopenia attributable to various causes. Platelet size was high or low in some dogs. The most clinically useful observation was that low mpv (microthrombocytosis) was a specific indicator of immune-mediated thrombocytopenia (imt) in these thrombocytopenic dogs. All but one case of microthrombocytosis (mpv< 5.4 fl) was found in dogs with imt. Microthrombocytosis was detected in 17 of 31 dogs with imt and appeared at the onset of the disease. Macrothrombocytosis (mpv > 9.4 fl) indicated active thrombopoiesis, but was not unique to any disease category. Macrothrombocytosis was detected in 18 of 31 dogs with imt, 3 of 17 dogs with disseminated intravascular coagulation, and 3 of 9 dogs with primary bone-marrow disease.

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