Study of feline leukemia virus immunity

Catherine Charreyre From the Department of Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616.

Search for other papers by Catherine Charreyre in
Current site
Google Scholar
PubMed
Close
 DEDV, MS
and
Niels C. Pedersen From the Department of Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616.

Search for other papers by Niels C. Pedersen in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Click on author name to view affiliation information

Summary

Fifteen specific-pathogen-free cats were experimentally infected with FeLV; 8 cats recovered after transient or nondetectable viremia, and 7 cats became persistently viremic. Four additional cats served as noninfected controls. Antibodies to whole FeLV (elisa and immunoblot [western] analysis), antibodies to fixed FeLV-infected cells, and virus-neutralizing antibodies were monitored for as long as 3 years after infection. As a group, cats that recovered after acute infection developed higher titer of these various antibodies than did cats that became persistently viremic. However, specific combination or titer of antibodies was not always found in recovered cats or in persistently viremic cats. Six cats that had recovered from acute FeLV infection nearly 3 years earlier were reinfected with the same virus. Three of the cats appeared to be resistant to reinfection, 2 cats became transiently viremic, and 1 cat became persistently viremic. Slight and transient anamnestic elisa-detectable antibody response to whole virus was seen after reinfection; immunofluoresence- and western blot-detectable responses were not greatly enhanced. Five FeLV-recovered cats were monitored for 2 years; FeLV infection spontaneously recurred in 1 cat.

Summary

Fifteen specific-pathogen-free cats were experimentally infected with FeLV; 8 cats recovered after transient or nondetectable viremia, and 7 cats became persistently viremic. Four additional cats served as noninfected controls. Antibodies to whole FeLV (elisa and immunoblot [western] analysis), antibodies to fixed FeLV-infected cells, and virus-neutralizing antibodies were monitored for as long as 3 years after infection. As a group, cats that recovered after acute infection developed higher titer of these various antibodies than did cats that became persistently viremic. However, specific combination or titer of antibodies was not always found in recovered cats or in persistently viremic cats. Six cats that had recovered from acute FeLV infection nearly 3 years earlier were reinfected with the same virus. Three of the cats appeared to be resistant to reinfection, 2 cats became transiently viremic, and 1 cat became persistently viremic. Slight and transient anamnestic elisa-detectable antibody response to whole virus was seen after reinfection; immunofluoresence- and western blot-detectable responses were not greatly enhanced. Five FeLV-recovered cats were monitored for 2 years; FeLV infection spontaneously recurred in 1 cat.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 427 427 137
PDF Downloads 34 34 4
Advertisement